将人类白细胞抗体检测结果应用于临床实践。

Incorporating human leukocyte antibody results into clinical practice.

作者信息

Tambur Anat R, Lavee Jacob

机构信息

Transplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Heart Transplantation Unit, Department of Cardiac Surgery, Leviev Heart Center, Sheba Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

J Heart Lung Transplant. 2016 Jul;35(7):851-6. doi: 10.1016/j.healun.2016.05.010. Epub 2016 May 20.

DOI:10.1016/j.healun.2016.05.010

PMID:27338026

Abstract

The use of human leukocyte antigen (HLA) antibody testing by solid-phase assay has improved both the specificity and sensitivity of HLA antibody detection. It did, however, introduce questions regarding interpretation of crossmatch results in light of these additional data. Herein we provide a clinician's and a laboratory professional's perspective on incorporating HLA results into clinical practice. We strongly encourage fostering ongoing dialog between the two disciplines to develop appropriate, specific guidelines.

摘要

通过固相分析法进行人类白细胞抗原（HLA）抗体检测，提高了HLA抗体检测的特异性和敏感性。然而，鉴于这些额外的数据，这确实引发了关于交叉配型结果解读的问题。在此，我们从临床医生和实验室专业人员的角度，阐述将HLA检测结果纳入临床实践的观点。我们强烈鼓励这两个学科之间开展持续对话，以制定适当、具体的指导原则。