Periodontology and Oral Implantology, University of the Andes, Chile.
Oral Prosthetic and Surgical Implantology, University of the Andes, Chile.
J Dent. 2016 Sep;52:23-9. doi: 10.1016/j.jdent.2016.06.005. Epub 2016 Jun 20.
This clinical trial explored the clinical and radiographic dimensional changes of the alveolar ridge in the first 4 months after tooth extraction in combination with the application of Leukocyte- and Platelet Rich Fibrin (L-PRF).
Eighteen single rooted maxillary and mandibular sockets were filled with L-PRF without soft tissue closure. Clinical measurements (bone sounding) were performed using a customized acrylic stent and radiographic measurements were accomplished using Cone Beam Computed Tomography (CBCT), immediately after tooth extraction and after 4 months.
The clinical observations indicated a mean horizontal resorption of 1.18±2.4mm (p=0.8) at the crest, 1.25±2.0mm (p=0.57) and 0.83±2.0mm (p=0.78) at 2mm and 4mm apical to the crest, respectively. The buccal plate demonstrated a mean vertical loss of 0.44±3.5mm (p=0.9), the centre of the socket had a significant filling of 5.72±3.6mm (p=0.0001) and the oral cortical plate had a mean vertical gain of 0.09mm±1.57mm (p=0.9). The radiographic analysis demonstrated a mean vertical bone loss of 0.27±2.5mm (p=0.9) on the buccal and of 0.03±1.6mm (p=0.9) at the oral crest. The width of the alveolar ridge had a mean loss of 1.33mm±1.43mm.
Within the limitations of this pilot study, it can be concluded that L-PRF might show clinical benefits for ridge preservation.
本临床试验探索了在拔牙后 4 个月内联合使用富白细胞和血小板纤维蛋白（L-PRF）治疗时牙槽嵴的临床和影像学的二维变化。
18 个上颌和下颌单个牙根牙槽窝内填充了 L-PRF，未进行软组织关闭。临床测量（骨探查）使用定制的丙烯酸支架进行，影像学测量使用锥形束 CT（CBCT）进行，分别在拔牙后即刻和 4 个月时进行。
临床观察显示，牙槽嵴顶的平均水平吸收为 1.18±2.4mm（p=0.8），牙槽嵴顶 2mm 和 4mm 处的平均水平吸收分别为 1.25±2.0mm（p=0.57）和 0.83±2.0mm（p=0.78）。颊侧骨板的平均垂直丧失为 0.44±3.5mm（p=0.9），牙槽窝的中心有明显的填充，为 5.72±3.6mm（p=0.0001），口腔皮质骨板的平均垂直获得为 0.09mm±1.57mm（p=0.9）。影像学分析显示，颊侧的平均垂直骨丧失为 0.27±2.5mm（p=0.9），牙槽嵴顶的平均垂直骨丧失为 0.03±1.6mm（p=0.9）。牙槽嵴的宽度平均丧失 1.33mm±1.43mm。
在本初步研究的限制内，可以得出结论，L-PRF 可能显示出对牙槽嵴保存的临床益处。
