Jakobi P, Krivoy N, Weissman A, Paldi E
Department of Gynecology and Obstetrics B, Rambam Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
Obstet Gynecol. 1989 Jul;74(1):29-33.
The objective of this study was to measure maternal total digoxin-like immunoreactive factor levels in singleton pregnancies with or without hypertension and in twin pregnancies. Plasma digoxin-like immunoreactive factor was measured in 113 third-trimester patients: 51 normotensives, 20 preeclamptics, 19 with latent or chronic hypertension, and 23 with twin pregnancies. The concentration of total digoxin-like immunoreactive factor in the twin gestations (1143 +/- 249 pg/mL) was significantly higher than that in either the normotensive pregnancies (890 +/- 161 pg/mL) (P less than .001) or in the hypertensive pregnancies (903 +/- 256 pg/mL) (P less than .01). However, there were no significant differences in digoxin-like immunoreactive factor levels between the normotensive and hypertensive groups. A trend of higher, although not statistically significant, levels of digoxin-like immunoreactive factor was noted in the chronic hypertensive group as compared with the preeclamptic patients (957 +/- 212 versus 852 +/- 288 pg/mL). We therefore conclude that digoxin-like immunoreactive factor does not contribute significantly to the pathogenesis or prediction of preeclampsia. The increased amount of digoxin-like immunoreactive factor in twin pregnancies may reflect a contribution from multifetal origin, or might be a physiologic adaptive mechanism allowing higher cardiac output by a possible cardiotropic effect.
本研究的目的是测量单胎妊娠伴或不伴高血压以及双胎妊娠孕妇的母体总地高辛样免疫反应因子水平。对113例孕晚期患者的血浆地高辛样免疫反应因子进行了测量：51例血压正常者、20例先兆子痫患者、19例隐匿性或慢性高血压患者以及23例双胎妊娠患者。双胎妊娠中总地高辛样免疫反应因子的浓度（1143±249 pg/mL）显著高于血压正常的妊娠（890±161 pg/mL）（P＜0.001）或高血压妊娠（903±256 pg/mL）（P＜0.01）。然而，血压正常组和高血压组之间的地高辛样免疫反应因子水平没有显著差异。与先兆子痫患者相比，慢性高血压组的地高辛样免疫反应因子水平虽无统计学意义但有升高趋势（957±212与852±288 pg/mL）。因此，我们得出结论，地高辛样免疫反应因子对先兆子痫的发病机制或预测没有显著作用。双胎妊娠中地高辛样免疫反应因子量的增加可能反映了多胎来源的影响，或者可能是一种生理适应性机制，通过可能的强心作用允许更高的心输出量。
