Heart Center, Luzerner Kantonsspital, Lucerne, Switzerland.
Swiss Cardiovascular Center, University Hospital Berne, Berne, Switzerland.
JACC Cardiovasc Interv. 2016 Jun 27;9(12):1269-1276. doi: 10.1016/j.jcin.2016.03.024. Epub 2016 Jun 20.
The study sought to identify predictors for delayed high-degree atrioventricular block (AVB) in patients undergoing transcatheter aortic valve replacement (TAVR) and determine the need and required duration of telemetry monitoring.
Little is known about predictors and timing of high-degree AVB.
A total of 1,064 patients (52% women) without a permanent pacemaker undergoing TAVR at 3 centers in Switzerland were investigated. Electrocardiograms (ECGs) at baseline and post-TAVR were analyzed to identify atrioventricular and interventricular conduction disorders.
Periprocedural high-degree AVB occurred in 92 (8.7%), delayed high-degree AVB in 71 (6.7%), up to 8 days post-procedure. In multivariate analysis, delayed high-degree AVB occurred more frequently in men (odds ratio: 2.4, 95% confidence interval: 1.3 to 4.5; p < 0.01), and in patients with conduction disorders post-TAVR (odds ratio: 10.8; 95% confidence interval: 4.6 to 25.5; p < 0.01). Patients in sinus rhythm without conduction disorders post-TAVR did not develop delayed high-degree AVB (0 of 250, 0%). Similarly, the risk in patients with atrial fibrillation but no other conduction disorders was very low (1 of 102, 1%). There was no patient developing delayed high-degree AVB who had a stable ECG for 2 days or more.
Patients without conduction disorders post-TAVR did not develop delayed high-degree AVB. Such patients may not require telemetry monitoring. All other patients should be monitored until the ECG remains stable for at least 2 days. This algorithm should be validated in a separate patient population.
本研究旨在确定行经导管主动脉瓣置换术(TAVR)的患者发生延迟性高度房室传导阻滞(AVB)的预测因素,并确定遥测监测的必要性和所需时间。
关于高度 AVB 的预测因素和发生时间知之甚少。
本研究共纳入了在瑞士 3 家中心接受 TAVR 的 1064 名(52%为女性)无永久性起搏器的患者。分析术前和术后的心电图(ECG),以确定房室和室间传导障碍。
92 名(8.7%)患者发生了围手术期高度 AVB,71 名(6.7%)患者发生了延迟性高度 AVB,发生时间在术后 8 天内。多变量分析显示,男性(比值比:2.4,95%置信区间:1.3 至 4.5;p<0.01)和术后存在传导障碍的患者更易发生延迟性高度 AVB,比值比分别为 10.8 和 4.6 至 25.5(p<0.01)。术后无传导障碍且节律为窦性的患者未发生延迟性高度 AVB(250 例中无 1 例,0%)。同样,无其他传导障碍且房颤的患者风险也非常低(102 例中 1 例,1%)。无 1 例延迟性高度 AVB 患者的心电图稳定 2 天或以上。
术后无传导障碍的患者不会发生延迟性高度 AVB。此类患者可能无需进行遥测监测。所有其他患者应在心电图稳定至少 2 天之前进行监测。该算法应在另一组患者中进行验证。