Burkhardt D, Ghosh P
Aust N Z J Surg. 1977 Oct;47(5):571-6. doi: 10.1111/j.1445-2197.1977.tb06585.x.
The effects of heat and its possible significance in cance therapy have been documented for more than a century. Hyperthermia has been widely investigated as an alternative or adjuvant to conventional therapies such as surgery, radiation, and chemotherapy. The clinical reports are interesting, notwithstanding some harmful side effects and other complications which, however, may be attributable to an advanced stage of the disease at the time of treatment. In view of the extreme difficulty in matching suitable controls for cancer patients undertaking such therapy, it is essential to extend knowledge of the effects of hyperthermia on normal and neoplastic tissue by experimental studies. Further, the different methods of utilizing heat therapy have need for substantial technological improvements. To stimulate interest in this area, we have gathered together in this review some of the more pertinent reports on the application of hyperthermia to neoplastic and normal tissues as observed clinically and in the laboratory.
热的作用及其在癌症治疗中的潜在意义已有一个多世纪的文献记载。作为手术、放疗和化疗等传统疗法的替代或辅助手段，热疗已得到广泛研究。尽管存在一些有害副作用和其他并发症，但临床报告仍很有趣，不过这些副作用和并发症可能归因于治疗时疾病已处于晚期。鉴于为接受此类治疗的癌症患者匹配合适对照极为困难，通过实验研究来扩展对热疗对正常组织和肿瘤组织影响的认识至关重要。此外，热疗的不同应用方法亟需大幅的技术改进。为激发对该领域的兴趣，我们在这篇综述中汇集了一些关于热疗在临床和实验室中应用于肿瘤组织和正常组织的更相关报告。
