Gupta Akhil, March Lyn
Royal North Shore Hospital, Sydney.
Rheumatology and Musculoskeletal Epidemiology, Northern Clinical School, University of Sydney.
Aust Prescr. 2016 Apr;39(2):40-6. doi: 10.18773/austprescr.2016.028. Epub 2016 Apr 1.
Osteoporotic fractures are common resulting in increased morbidity and mortality. Exercise can help prevent osteoporosis. It can also benefit patients with osteoporosis, but the exercises must be tailored to the patient. Most Australians should be able to obtain adequate calcium in their diet and vitamin D from the sun. Supplements may be needed in some patients and they are recommended for use with other drugs for osteoporosis. Bisphosphonates, and in some patients denosumab, are first-line drugs for osteoporosis. Raloxifene and strontium ranelate can be considered in patients who cannot take bisphosphonates or denosumab. Teriparatide is reserved for patients with severe osteoporosis and the use of strontium ranelate is declining because of cardiovascular safety concerns.
骨质疏松性骨折很常见,会导致发病率和死亡率上升。运动有助于预防骨质疏松症。它对骨质疏松症患者也有益处,但运动必须根据患者情况量身定制。大多数澳大利亚人应该能够从饮食中获取足够的钙,并通过晒太阳获得维生素D。一些患者可能需要补充剂,建议与其他治疗骨质疏松症的药物一起使用。双膦酸盐,在一些患者中还有地诺单抗,是治疗骨质疏松症的一线药物。不能服用双膦酸盐或地诺单抗的患者可考虑使用雷洛昔芬和雷奈酸锶。特立帕肽 reserved for patients with severe osteoporosis and the use of strontium ranelate is declining because of cardiovascular safety concerns.(原文此处表述有误,正确内容应该是“特立帕肽用于治疗严重骨质疏松症患者,由于心血管安全性问题,雷奈酸锶的使用正在减少。”)