Jung Woo-Sang, Kwon Seungwon, Cho Seung-Yeon, Park Seong-Uk, Moon Sang-Kwan, Park Jung-Mi, Ko Chang-Nam, Cho Ki-Ho
Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Evid Based Complement Alternat Med. 2016;2016:2601740. doi: 10.1155/2016/2601740. Epub 2016 Jun 2.
Chunghyul-dan (CHD) is a herbal complex containing 80% ethanol extract and is composed of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, and Rhei Rhizoma. We have published several experimental and clinical research articles on CHD. It has shown antilipidemic, antihypertensive, antiatherosclerotic, and inhibitory effects on ischemic stroke recurrence with clinical safety in the previous studies. The antilipidemic effect of CHD results from 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and pancreatic lipase-inhibitory activity. The antihypertensive effect likely results from the inhibitory effect on endogenous catecholamine(s) release and harmonization of all components showing the antihypertensive effects. Furthermore, anti-inflammatory and antioxidant effects on endothelial cells are implicated to dictate the antiatherosclerotic effects of CHD. It also showed neuroprotective effects on cerebrovascular and parkinsonian models. These effects of CHD could be helpful for the prevention of the recurrence of ischemic stroke. Therefore, we suggest that CHD could be a promising medication for treating and preventing cerebrovascular and cardiovascular diseases. However, to validate and better understand these findings, well-designed clinical studies are required.
柴胡丹（CHD）是一种含有80%乙醇提取物的草药复合物，由黄芩、黄连、黄柏、栀子和大黄组成。我们已经发表了几篇关于CHD的实验和临床研究文章。在之前的研究中，它已显示出抗血脂、降压、抗动脉粥样硬化以及对缺血性中风复发的抑制作用，且具有临床安全性。CHD的抗血脂作用源于3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶和胰脂肪酶抑制活性。降压作用可能源于对内源性儿茶酚胺释放的抑制作用以及所有具有降压作用成分的协同作用。此外，对内皮细胞的抗炎和抗氧化作用被认为是CHD抗动脉粥样硬化作用的原因。它在脑血管和帕金森病模型中也显示出神经保护作用。CHD的这些作用可能有助于预防缺血性中风的复发。因此，我们认为CHD可能是一种治疗和预防脑血管及心血管疾病的有前景的药物。然而，为了验证并更好地理解这些发现，需要设计良好的临床研究。
