Farhana Kun Marisa, Malueka Rusdy Ghazali, Wibowo Samekto, Gofir Abdul
Department of Neurology, Faculty of Medicine, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta 55284, Indonesia.
Evid Based Complement Alternat Med. 2016;2016:2795915. doi: 10.1155/2016/2795915. Epub 2016 Jun 1.
This study aimed to determine the effectiveness of gotu kola (Centella asiatica) in improving cognitive function in patients with vascular cognitive impairment (VCI). This study uses a quasi-experimental design. Subjects in this study were patients with poststroke cognitive impairment who were treated at two hospitals in Yogyakarta, Indonesia. The number of subjects was 48: 17 subjects were treated with 1000 mg/day of gotu kola extract, 17 subjects treated with 750 mg/day of gotu kola extract, and 14 subjects treated with 3 mg/day of folic acid for 6 weeks. A Montreal Cognitive Assessment-Indonesian version (MoCA-Ina) was conducted at the beginning of treatment and after 6 weeks of therapy. It was found that all trials effectively improved poststroke VCI based on MoCA-Ina scores over the course of the study. There is no significant difference in ΔMoCA-Ina (score at the 6th week of treatment - score at the beginning) mean score among the three groups, indicating that gotu kola is as effective as folic acid in improving poststroke VCI. Gotu kola was shown to be more effective than folic acid in improving memory domain. This study suggested that gotu kola extract is effective in improving cognitive function after stroke.
本研究旨在确定积雪草（Centella asiatica）对改善血管性认知障碍（VCI）患者认知功能的有效性。本研究采用准实验设计。本研究的受试者为在印度尼西亚日惹的两家医院接受治疗的中风后认知障碍患者。受试者人数为48人：17名受试者接受每天1000毫克积雪草提取物治疗，17名受试者接受每天750毫克积雪草提取物治疗，14名受试者接受每天3毫克叶酸治疗，为期6周。在治疗开始时和治疗6周后进行了印度尼西亚版蒙特利尔认知评估（MoCA-Ina）。结果发现，在整个研究过程中，根据MoCA-Ina评分，所有试验均有效改善了中风后VCI。三组之间的ΔMoCA-Ina（治疗第6周的分数 - 开始时的分数）平均分数没有显著差异，表明积雪草在改善中风后VCI方面与叶酸一样有效。积雪草在改善记忆领域方面比叶酸更有效。本研究表明，积雪草提取物对改善中风后的认知功能有效。
