通过钯催化的导向基团一锅法安装和C(sp(3))-H芳基化合成β-芳基烷基酰胺
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))-H arylation.
作者信息
Liu Yunyun, Zhang Yi, Cao Xiaoji, Wan Jie-Ping
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022 P. R. China.
Research Center of Analysis and Measurement, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, Zhejiang 310014, P.R. China.
出版信息
Beilstein J Org Chem. 2016 Jun 3;12:1122-6. doi: 10.3762/bjoc.12.108. eCollection 2016.
Abstract
The synthesis of β-arylated alkylamides via alkyl C-H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed.
摘要
通过酰氯、芳基碘化物和8-氨基喹啉的直接一锅法反应，实现了经由烷基C-H键芳基化合成β-芳基化烷基酰胺。根据起始原料的结构，可以得到单β-芳基化烷基酰胺和双β-芳基化烷基酰胺。
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