通过邻氨基酚（OAP）导向的 C(sp)-H 芳基化反应实现多样的邻芳基苯甲酰胺的多组分合成。
Multicomponent Synthesis of Diverse o-Arylated Benzamides via o-Aminophenol (OAP) Directed C(sp)-H Arylation.
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, China.
出版信息
J Org Chem. 2017 Sep 1;82(17):8950-8957. doi: 10.1021/acs.joc.7b01375. Epub 2017 Aug 17.
o-Aminophenol (OAP) has been discovered as practical precursor of directing group (DG) in the palladium-catalyzed aromatic C-H arylation of benzamides. This newly identified, simple, and low cost DG has exhibited broad substrate tolerance in the rapid synthesis of various o-arylated benzamides via direct assemblies of benzoyl chlorides, aryl iodides, and different o-aminophenols in the form of step economical multicomponent reaction.
邻氨基酚（OAP）已被发现是钯催化苯甲酰胺芳基 C-H 芳基化反应中实用的导向基团（DG）前体。这种新发现的、简单的、低成本的 DG 在通过苯甲酰氯、芳基碘化物和不同邻氨基酚的直接组装，以经济的多组分反应形式快速合成各种邻芳基苯甲酰胺的反应中表现出广泛的底物耐受性。
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