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本文引用的文献

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Knee Cartilage Defect Patients Enrolled in Randomized Controlled Trials Are Not Representative of Patients in Orthopedic Practice.随机对照试验纳入的膝关节软骨缺损患者不能代表骨科实践中的患者。
Cartilage. 2010 Oct;1(4):312-9. doi: 10.1177/1947603510373917.
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Osteochondral repair using a scaffold-free tissue-engineered construct derived from synovial mesenchymal stem cells and a hydroxyapatite-based artificial bone.使用源自滑膜间充质干细胞和羟基磷灰石基人工骨的无支架组织工程构建体进行骨软骨修复。
Tissue Eng Part A. 2014 Sep;20(17-18):2291-304. doi: 10.1089/ten.tea.2013.0414. Epub 2014 Mar 21.
3
Osteochondral tissue engineering with biphasic scaffold: current strategies and techniques.采用双相支架的骨软骨组织工程：当前策略与技术
Tissue Eng Part B Rev. 2014 Oct;20(5):468-76. doi: 10.1089/ten.TEB.2013.0543. Epub 2014 Feb 26.
4
Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect model.在小鼠关节缺损模型中通过诱导多能干细胞移植进行骨与软骨修复
Biomed Res. 2013;34(6):281-8. doi: 10.2220/biomedres.34.281.
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Cyclic hydrostatic pressure promotes a stable cartilage phenotype and enhances the functional development of cartilaginous grafts engineered using multipotent stromal cells isolated from bone marrow and infrapatellar fat pad.周期性流体静压可促进稳定的软骨表型，并增强使用从骨髓和髌下脂肪垫分离的多能基质细胞构建的软骨移植物的功能发育。
J Biomech. 2014 Jun 27;47(9):2115-21. doi: 10.1016/j.jbiomech.2013.12.006. Epub 2013 Dec 13.
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Perspectives in multiphasic osteochondral tissue engineering.多相骨软骨组织工程的观点。
Anat Rec (Hoboken). 2014 Jan;297(1):26-35. doi: 10.1002/ar.22795. Epub 2013 Dec 2.
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Functional properties of bone marrow-derived MSC-based engineered cartilage are unstable with very long-term in vitro culture.基于骨髓间充质干细胞的工程软骨的功能特性在非常长期的体外培养中不稳定。
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Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes.运动员全层膝关节软骨损伤微骨折治疗后的长期疗效
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The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold.联合关节内注射甲状旁腺素相关蛋白和双层胶原-丝素支架植入促进软骨修复。
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软骨修复的细胞和非细胞方法：哲学分析

Cellular and Acellular Approaches for Cartilage Repair: A Philosophical Analysis.

作者信息

Brittberg Mats

机构信息

Cartilage Research Unit, University of Gothenburg, Gothenburg, Sweden; Region Halland Orthopaedics, Kungsbacka Hospital, Kungsbacka, Sweden.

出版信息

Cartilage. 2015 Apr;6(2 Suppl):4S-12S. doi: 10.1177/1947603514536983. Epub 2015 Mar 24.

DOI:10.1177/1947603514536983
PMID:27340516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4481382/
Abstract

There are several choices of cells to use for cartilage repair. Cells are used as internal or external sources and sometimes in combination. In this article, an analysis of the different cell choices and their use and potential is provided. Embryonic cartilage formation is of importance when finding more about how to be able to perfect cartilage repair. Some suggestions for near future research based on up-to-date knowledge on chondrogenic cells are given to hopefully stimulate more studies on the final goal of cartilage regeneration.

摘要

用于软骨修复的细胞有多种选择。细胞可作为内部或外部来源使用，有时也会联合使用。本文对不同的细胞选择及其应用和潜力进行了分析。在深入了解如何实现完美的软骨修复时，胚胎软骨形成具有重要意义。基于软骨生成细胞的最新知识，给出了一些对近期研究的建议，以期激发更多关于软骨再生最终目标的研究。