Nairn R C, Nind A P, Pihl E, Ceredig R, Jablonka I M, Cuthbertson A M, Hughes E S, Rollo A J
Aust N Z J Surg. 1977 Oct;47(5):637-41. doi: 10.1111/j.1445-2197.1977.tb06595.x.
Twenty-five patients with colorectal carcinoma were tested for blood-lymphocyte anti-tumour cytotoxicity and carcinoembryonic antigen (CEA) levels at three-monthly intervals for eighteen months or more after resection, and examined clinically every three to six months. Twelve of the patients were followed for two years and one for four years. The six patients whose tumours recurred showed positive blood lymphocyte antitumour cytotoxicity and elevated plasma CEA levels at some time from six months after operation, usually well before the recurrence was clinically detectable.
对25例结肠直肠癌患者在切除术后每三个月检测一次血淋巴细胞抗肿瘤细胞毒性和癌胚抗原（CEA）水平，持续18个月或更长时间，并每三至六个月进行一次临床检查。其中12例患者随访了两年，1例随访了四年。6例肿瘤复发的患者在术后6个月后的某个时间显示出血淋巴细胞抗肿瘤细胞毒性阳性和血浆CEA水平升高，通常远在临床可检测到复发之前。
