Gardiner F W, Zhai S
Calvary Hospital Bruce, Canberra, Australia.
Ir J Med Sci. 2017 Feb;186(1):213-218. doi: 10.1007/s11845-016-1476-9. Epub 2016 Jun 24.
Cardiac Troponin I and Troponin T are both very sensitive and specific, with the troponin pathology test recommended for the diagnosis of myocardial infarction. The diagnosis of myocardial infarction, in conjunction with electrocardiogram myocardial infarction, is based on a rise or fall of troponin with at least one value above the 99th percentile for the population. Troponin levels are regularly ordered within hospitals, especially in emergency medicine. It has been suggested that much of this testing is ordered despite the absence of clinical suspicion for acute coronary syndrome.
This study examined the appropriateness of troponin testing within one Australian teaching hospital.
A retrospective chart review was conducted of 111 randomly selected patients who received a troponin assay within the hospital's Emergency Department. To determine appropriateness, the troponin test needed to reflect Australian clinical guidelines, and inform the ongoing management of the patient.
Results demonstrate that the majority (76.6 %) of troponin testing was appropriate, with the remainder (23.4 %) deemed inappropriate due to not altering the ongoing patient management (n = 26), and not being informed by clinical guidelines (n = 26).
Troponin testing is important in the diagnosis of myocardial infarction, although should not be ordered routinely, or unnecessary. This study has determined that using clinical guidelines can promote rational ordering, and that testing should ultimately benefit patient management. Reducing inappropriate pathology test ordering is important to maximize productive clinical time, reduce false positives, maximize patient care, and to reduce financial waste.
心肌肌钙蛋白I和肌钙蛋白T都具有很高的敏感性和特异性,肌钙蛋白病理检查被推荐用于诊断心肌梗死。心肌梗死的诊断结合心电图心肌梗死表现,基于肌钙蛋白的升高或降低,且至少有一个值高于人群第99百分位数。医院内经常会开具肌钙蛋白检测项目,尤其是在急诊医学中。有人认为,尽管没有急性冠状动脉综合征的临床怀疑,很多这类检测仍被开具。
本研究调查了澳大利亚一家教学医院内肌钙蛋白检测的合理性。
对在医院急诊科接受肌钙蛋白检测的111名随机选择的患者进行回顾性病历审查。为确定合理性,肌钙蛋白检测需符合澳大利亚临床指南,并为患者的持续管理提供信息。
结果表明,大多数(76.6%)肌钙蛋白检测是合理的,其余(23.4%)被认为不合理,原因是未改变患者的持续管理(n = 26),以及未依据临床指南进行检测(n = 26)。
肌钙蛋白检测在心肌梗死诊断中很重要,尽管不应常规或不必要地开具。本研究确定,使用临床指南可促进合理开具检测项目,且检测最终应有利于患者管理。减少不适当的病理检查开具对于最大化有效的临床时间、减少假阳性、最大化患者护理以及减少财务浪费很重要。