一种新型古洛糖醛酸低聚物可改善囊性纤维化小鼠的肠道转运并提高其存活率。
A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice.
作者信息
Vitko Megan, Valerio Dana M, Rye Philip D, Onsøyen Edvar, Myrset Astrid H, Dessen Arne, Drumm Mitchell L, Hodges Craig A
机构信息
Department of Genetics and Genome Sciences, Case Western Reserve University, United States.
Department of Pediatrics, Case Western Reserve University, United States.
出版信息
J Cyst Fibros. 2016 Nov;15(6):745-751. doi: 10.1016/j.jcf.2016.06.005. Epub 2016 Jun 21.
BACKGROUND
Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing intestinal mucus and subsequent CF-related intestinal manifestations.
METHODS
Intestinal transit, intestinal histology, survival and growth were examined in wildtype and CF mice on regular water and OligoG.
CONCLUSIONS
OligoG improves intestinal transit and survival in CF mice by reducing the accumulation of intestinal mucus. OligoG's ability to directly bind mucin, disrupt mucin interaction and/or sequester calcium allowing for mucin expansion may explain the decrease in mucus accumulation.
背景
囊性纤维化（CF）患者会出现以浓稠粘性黏液积聚为特征的肠道并发症。利用CF小鼠来确定一种新型古洛糖醛酸寡聚物OligoG是否可能成为减少肠道黏液及后续CF相关肠道表现的潜在疗法。
方法
对饮用常规水和OligoG的野生型和CF小鼠的肠道转运、肠道组织学、生存和生长情况进行了检查。
结论
OligoG通过减少肠道黏液的积聚改善了CF小鼠的肠道转运和生存情况。OligoG直接结合黏蛋白、破坏黏蛋白相互作用和/或螯合钙从而使黏蛋白扩张的能力，可能解释了黏液积聚的减少。
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