Schostek Sebastian, Zimmermann Melanie, Keller Jan, Fode Mario, Melbert Michael, Schurr Marc O, Gottwald Thomas, Prosst Ruediger L
Ovesco Endoscopy AG, Dorfackerstr. 26, 72074, Tuebingen, Germany.
IHCI Institute, Steinbeis University Berlin, Tuebingen, Germany.
Dig Dis Sci. 2016 Oct;61(10):2956-2962. doi: 10.1007/s10620-016-4226-y. Epub 2016 Jun 24.
An acute upper gastrointestinal bleeding event is an emergency situation which requires immediate endoscopic assessment and treatment. A new telemetric real-time intracorporeal bleeding sensor can help in the timely diagnosis of an acute upper gastrointestinal bleeding event: The sensor capsule, HemoPill, is swallowed by the patient if gastrointestinal bleeding is suspected. Information about the bleeding status is displayed by telemetric communication of the capsule with an extracorporeal receiver. This is the first evaluation of the HemoPill to detect blood in the upper human gastrointestinal tract.
A voluntary test person ate a defined meal with or without the adjunct of his own blood for a total of eight times and afterward swallowed the sensor capsule. The collected spectrometric receiver data were analyzed to assess whether the sensor system was capable of detecting blood and to evaluate the effect of stomach content as an artifact.
With its optical sensor, the HemoPill was able to reliably indicate the ingested blood in the stomach. The data transmission from the swallowed sensor capsule to the extracorporeal receiver was achieved consistently. The evaluation of diverse concentrations of ingested blood and the respective sensor signals led to an exponential relationship of these variables. This relationship allows to define thresholds for categories indicating the likelihood of blood presence in the gastrointestinal tract.
The HemoPill is a valuable tool to detect an acute upper gastrointestinal bleeding event without the need of endoscopy.
急性上消化道出血事件是一种紧急情况，需要立即进行内镜评估和治疗。一种新型的遥测实时体内出血传感器有助于及时诊断急性上消化道出血事件：如果怀疑有胃肠道出血，患者可吞服传感器胶囊HemoPill。通过胶囊与体外接收器的遥测通信显示出血状态信息。这是对HemoPill检测人体上消化道血液的首次评估。
一名自愿测试者共八次进食规定餐食，其中有的餐食添加了其自身血液，有的未添加，之后吞服传感器胶囊。对收集到的光谱接收器数据进行分析，以评估传感器系统是否能够检测到血液，并评估胃内容物作为伪影的影响。
HemoPill凭借其光学传感器能够可靠地指示胃内摄入的血液。从吞服的传感器胶囊到体外接收器的数据传输始终能够实现。对不同浓度摄入血液和相应传感器信号的评估得出了这些变量之间的指数关系。这种关系有助于定义表示胃肠道内存在血液可能性的类别阈值。
HemoPill是一种无需内镜检查即可检测急性上消化道出血事件的有价值工具。
