Wei Xiangyu, Xi Peipei, Chen Minjie, Wen Ya, Wu Hao, Wang Li, Zhu Yujuan, Ren Yile, Gu Zhifeng
Department of Rheumatology, Research Center of Immunology, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
Department of Rheumatology, Affiliated Municipal Hospital of Xuzhou Medical University, Xuzhou, 221100, China.
Mater Today Bio. 2024 Oct 9;29:101294. doi: 10.1016/j.mtbio.2024.101294. eCollection 2024 Dec.
Current evidence suggests that the intestine as the new frontier for human health directly impacts both our physical and mental health. Therefore, it is highly desirable to develop the intelligent tool for the enhanced diagnosis and treatment of intestinal diseases. During the past 20 years, capsule robots have opened new avenues for research and clinical applications, potentially revolutionizing human health monitor, disease diagnosis and treatment. In this review, we summarize the research progress of edible multifunctional capsule robots in intestinal diseases. To begin, we introduce the correlation between the intestinal microbiome, intestinal gas and human diseases. After that, we focus on the technical structure of edible multifunctional robots. Subsequently, the biomedical applications in the monitoring, diagnosis and treatment of intestinal diseases are discussed in detail. Last but not least, the main challenges of multifunctional capsule robots during the development process are summarized, followed by a vision for future development opportunities.
目前的证据表明，肠道作为人类健康的新前沿，直接影响我们的身心健康。因此，开发用于增强肠道疾病诊断和治疗的智能工具非常必要。在过去20年中，胶囊机器人为研究和临床应用开辟了新途径，有可能彻底改变人类健康监测、疾病诊断和治疗。在这篇综述中，我们总结了可食用多功能胶囊机器人在肠道疾病方面的研究进展。首先，我们介绍肠道微生物群、肠道气体与人类疾病之间的相关性。之后，我们重点关注可食用多功能机器人的技术结构。随后，详细讨论其在肠道疾病监测、诊断和治疗中的生物医学应用。最后但同样重要的是，总结了多功能胶囊机器人在开发过程中的主要挑战，随后展望了未来的发展机遇。
