由巴甫洛夫条件反射介导的对戊巴比妥致死性的保护作用。

Protection from pentobarbital lethality mediated by Pavlovian conditioning.

作者信息

Vila J

机构信息

Maestria en Farmacologia Conductual, Escuela Nacional de Estudios Profesionales Iztacala.

出版信息

Pharmacol Biochem Behav. 1989 Jan;32(1):365-6. doi: 10.1016/0091-3057(89)90257-8.

DOI:10.1016/0091-3057(89)90257-8

PMID:2734348

Abstract

The lethal effects of pentobarbital overdose were dependent upon the context in which the drug was administered. Rats received repeated injections of pentobarbital (30 mg/kg), in a distinctive environment and saline in the home room. At test, rats received a large dose (95 mg/kg) of pentobarbital. Fewer deaths occurred in a contex previously associated with drug administration. The results are consistent with a Pavlovian model of drug tolerance.

摘要

戊巴比妥过量的致死效应取决于给药时的环境。大鼠在一个独特的环境中反复注射戊巴比妥（30毫克/千克），并在家中房间注射生理盐水。在测试时，大鼠接受大剂量（95毫克/千克）的戊巴比妥。在先前与药物给药相关的环境中死亡的大鼠较少。这些结果与巴甫洛夫式的药物耐受性模型一致。