Bartels M, Hornung K, Schied H W
Sektion Klinische Neurophysiologie der Universitäts-Nervenklinik Tübingen.
Psychiatr Prax. 1989 May;16(3):109-12.
Nine patients are reported with marked cerebellar side-effects under antidepressant treatment, mostly in combination with other psychopharmacological agents. The main symptoms were dysmetria, ataxia, intentional tremor, dysarthria and rarely myocloni. In nearly all cases symptomatology disappeared by slight dosis reduction of the antidepressant. Pathophysiology could be best explained by influence on nonadrenergic afferences of cerebellar cortex.
据报道，9例患者在抗抑郁治疗期间出现明显的小脑副作用，多数与其他精神药物联合使用。主要症状为辨距不良、共济失调、意向性震颤、构音障碍，很少有肌阵挛。几乎在所有病例中，通过轻微减少抗抑郁药剂量，症状均消失。病理生理学最好用对小脑皮质非肾上腺素能传入神经的影响来解释。
