Sugiura Tomonori, Dohi Yasuaki, Takase Hiroyuki, Yamashita Sumiyo, Murai Shunsuke, Tsuzuki Yuji, Ogawa Shintaro, Tanaka Yasuhito, Ohte Nobuyuki
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Department of Internal Medicine, Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan.
Atherosclerosis. 2016 Aug;251:192-196. doi: 10.1016/j.atherosclerosis.2016.06.027. Epub 2016 Jun 16.
Mac-2 binding protein (M2BP) was reported to be a useful biomarker for liver fibrosis and malignant tumors. We hypothesized that expression of M2BP might also change in the process of atherosclerosis.
This study included subjects who visited our hospital for a physical checkup.
The M2BP levels in subjects with hypertension, dyslipidemia, or abnormal glucose metabolism were higher than those in subjects without such risk factors. Moreover, the M2BP levels were associated with severity of cardiovascular risk. Subdivision of M2BP levels into quartiles revealed that M2BP was significantly associated with reactive oxygen metabolites, central systolic blood pressure, and radial augmentation index (AI). Logistic regression analysis with the endpoint of high radial AI (above mean value) showed that high radial AI was independently associated with high M2BP.
Although the spectrum was narrow as compared to that in cases of hepatic fibrosis, serum M2BP may reflect silent atherosclerosis in apparently healthy subjects.
据报道，Mac-2结合蛋白（M2BP）是肝纤维化和恶性肿瘤的一种有用生物标志物。我们推测，M2BP的表达在动脉粥样硬化过程中可能也会发生变化。
本研究纳入了来我院进行体检的受试者。
患有高血压、血脂异常或糖代谢异常的受试者的M2BP水平高于无此类危险因素的受试者。此外，M2BP水平与心血管风险的严重程度相关。将M2BP水平分为四分位数显示，M2BP与活性氧代谢产物、中心收缩压和桡动脉增强指数（AI）显著相关。以高桡动脉AI（高于平均值）为终点的逻辑回归分析显示，高桡动脉AI与高M2BP独立相关。
尽管与肝纤维化病例相比范围较窄，但血清M2BP可能反映明显健康受试者的隐匿性动脉粥样硬化。
