首发精神病中未治疗精神病持续时间与神经认知及社会认知之间的关系。
Relationship between duration of untreated psychosis and neurocognition and social cognition in first-episode psychosis.
作者信息
On Zhi Xiang, Cotton Susan, Farhall John, Killackey Eóin, Allott Kelly
机构信息
Department of Psychology and Counselling, La Trobe University, Australia.
Orygen, The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.
出版信息
Schizophr Res. 2016 Oct;176(2-3):529-532. doi: 10.1016/j.schres.2016.06.018. Epub 2016 Jun 23.
Cognitive impairment is common in first-episode psychosis (FEP); however, the relationship between duration of untreated psychosis (DUP) and neurocognition remains controversial, and no studies have examined the relationship between DUP and social cognition. This study involved secondary data analysis of baseline data from a randomised controlled trial of supported employment; 122 out 146 young people with FEP met inclusion criteria for this study. Results showed that DUP was not associated with neurocognitive or social cognitive performance. Results do not provide support for the neurotoxicity hypothesis of psychosis.
认知障碍在首发精神病（FEP）中很常见；然而，未治疗精神病持续时间（DUP）与神经认知之间的关系仍存在争议，且尚无研究探讨DUP与社会认知之间的关系。本研究涉及对一项支持性就业随机对照试验的基线数据进行二次数据分析；146名患有FEP的年轻人中有122名符合本研究的纳入标准。结果显示，DUP与神经认知或社会认知表现无关。研究结果不支持精神病的神经毒性假说。
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