2016年基思·L·帕克纪念讲座主讲人介绍：道格拉斯·M·斯托科博士
Introduction to the 2016 Keith L. Parker Memorial Lecturer: Douglas M. Stocco, Ph.D.
作者信息
Miller Walter L
机构信息
Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Mol Cell Endocrinol. 2017 Feb 5;441:2-6. doi: 10.1016/j.mce.2016.06.024. Epub 2016 Jun 21.
Douglas M. (Doug) Stocco is Professor Emeritus at Texas Tech University Health Sciences Center in Lubbock, TX, and is internationally renowned for his work characterizing the steroidogenic acute regulatory protein, StAR. Stocco's laboratory isolated and cloned StAR from mouse Leydig MA-10 cells, collaborated on the demonstration that StAR mutations cause congenital lipoid adrenal hyperplasia, and delineated much of what is known about the intracellular pathways that regulate its production. This work resolved a decades-long quest to identify the mechanism underlying the acute regulation of steroidogenesis.
道格拉斯·M.（道格）·斯托科是德克萨斯州拉伯克市德州理工大学健康科学中心的名誉教授，他因对类固醇生成急性调节蛋白（StAR）进行表征的工作而在国际上享有盛誉。斯托科的实验室从小鼠睾丸间质MA-10细胞中分离并克隆了StAR，合作证明了StAR突变会导致先天性类脂性肾上腺增生，并阐明了许多关于调节其产生的细胞内途径的已知信息。这项工作解决了长达数十年寻找类固醇生成急性调节机制的难题。
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