昼夜不停的DNA损伤与衰老
DNA Damage and Aging Around the Clock.
作者信息
Gutierrez-Martinez Paula, Rossi Derrick J, Beerman Isabel
机构信息
Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
出版信息
Trends Mol Med. 2016 Aug;22(8):635-637. doi: 10.1016/j.molmed.2016.06.006. Epub 2016 Jun 23.
The hematopoietic system undergoes many changes during aging, but the causes and molecular mechanisms behind these changes are not well understood. Wang et al. have recently implicated a circadian rhythm gene, Per2, as playing a role in the DNA damage response and in the expression of lymphoid genes in aged hematopoietic stem cells.
造血系统在衰老过程中会发生许多变化，但其背后的原因和分子机制尚未完全明确。Wang等人最近指出，昼夜节律基因Per2在老年造血干细胞的DNA损伤反应和淋巴基因表达中发挥作用。
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