[前庭神经鞘瘤不同生物学行为分子机制的研究进展]

[Research advances in molecular mechanisms underlying the different biological behaviors of vestibular schwannoma].

作者信息

Wang Z Y, Yang J, Wu H

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Jiaotong University Ear Institute, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200092, China; Department of Otorhinolaryngology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jun 7;51(6):473-5. doi: 10.3760/cma.j.issn.1673-0860.2016.06.020.

DOI:10.3760/cma.j.issn.1673-0860.2016.06.020

PMID:27345892

Abstract

Current treatment options of vestibular schwannomas should not be limited to conventional surgery because of the variability of tumor growth. Recent studies of vestibular schwannomas suggested that the development of the tumor tended to depend on the shuttle between the nucleus and cytoplasm, and the expression patterns of merlin protein. New drug targets for schwannoma therapies might be identified through future in-depth investigations of the function of merlin, thus contributing to tumor control.

摘要

由于前庭神经鞘瘤生长的变异性，目前其治疗选择不应局限于传统手术。最近关于前庭神经鞘瘤的研究表明，肿瘤的发展往往取决于细胞核与细胞质之间的穿梭以及默林蛋白的表达模式。通过未来对默林功能的深入研究，可能会确定神经鞘瘤治疗的新药物靶点，从而有助于控制肿瘤。