Ulug P, Powell J T, Sweeting M J, Bown M J, Thompson S G
Vascular Surgery Research Group, Imperial College London, London, UK.
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Br J Surg. 2016 Aug;103(9):1097-104. doi: 10.1002/bjs.10225. Epub 2016 Jun 27.
Although women represent an increasing proportion of those presenting with abdominal aortic aneurysm (AAA) rupture, the current prevalence of AAA in women is unknown. The contemporary population prevalence of screen-detected AAA in women was investigated by both age and smoking status.
A systematic review was undertaken of studies screening for AAA, including over 1000 women, aged at least 60 years, done since the year 2000. Studies were identified by searching MEDLINE, Embase and CENTRAL databases until 13 January 2016. Study quality was assessed using the Newcastle-Ottawa scoring system.
Eight studies were identified, including only three based on population registers. The largest studies were based on self-purchase of screening. Altogether 1 537 633 women were screened. Overall AAA prevalence rates were very heterogeneous, ranging from 0·37 to 1·53 per cent: pooled prevalence 0·74 (95 per cent c.i. 0·53 to 1·03) per cent. The pooled prevalence increased with both age (more than 1 per cent for women aged over 70 years) and smoking (more than 1 per cent for ever smokers and over 2 per cent in current smokers).
The current population prevalence of screen-detected AAA in older women is subject to wide demographic variation. However, in ever smokers and those over 70 years of age, the prevalence is over 1 per cent.
尽管女性在腹主动脉瘤（AAA）破裂患者中所占比例日益增加，但目前女性AAA的患病率尚不清楚。本研究按年龄和吸烟状况调查了经筛查发现的女性AAA在当代人群中的患病率。
对2000年以来开展的针对AAA的筛查研究进行系统综述，这些研究纳入了至少1000名60岁及以上的女性。通过检索MEDLINE、Embase和CENTRAL数据库直至2016年1月13日来确定相关研究。使用纽卡斯尔-渥太华评分系统评估研究质量。
共识别出8项研究，其中只有3项基于人口登记数据。规模最大的研究基于自我购买筛查服务。总计对1537633名女性进行了筛查。总体AAA患病率差异很大，范围为0.37%至1.53%：合并患病率为0.74%（95%置信区间为0.53%至1.03%）。合并患病率随年龄（70岁以上女性超过1%）和吸烟情况（既往吸烟者超过1%，当前吸烟者超过2%）的增加而升高。
目前经筛查发现的老年女性AAA在人群中的患病率存在很大的人口统计学差异。然而，在既往吸烟者和70岁以上人群中，患病率超过1%。
