Vesely D L
Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock.
South Med J. 1989 Jun;82(6):758-61.
I have described a 21-year-old man who had biopsy-proven hypothalamic sarcoidosis and polyphagia with a weight increase to 393 lb (178.6 kg) on a 5 ft 4 inch frame during a seven-year follow-up. This morbid obesity appears to be due to sarcoid invasion of the satiety center in the ventral medial nucleus of the hypothalamus. In addition, sarcoid invasion of the supraoptic nucleus produced partial diabetes insipidus. Anterior pituitary deficiency, with complete gonadotropin and growth hormone deficiency, as well as partial ACTH and TSH deficiency, were also present.
我曾描述过一名21岁男性，经活检证实患有下丘脑结节病，在长达七年的随访期间出现多食症状，身高5英尺4英寸（约1.63米）的他体重增至393磅（178.6千克）。这种病态肥胖似乎是由于结节侵犯了下丘脑腹内侧核的饱食中枢所致。此外，视上核受结节侵犯导致部分尿崩症。同时还存在垂体前叶功能减退，伴有完全性促性腺激素和生长激素缺乏，以及部分促肾上腺皮质激素和促甲状腺激素缺乏。
