Harada K, Shiino A, Matsuda M, Handa J
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan.
Surg Neurol. 1989 Jul;32(1):16-20. doi: 10.1016/0090-3019(89)90030-x.
Effects of a novel calcium 2+ antagonist, KB-2796, on neurologic outcome and size of infarction were studied in the rat model of focal cerebral ischemia. Neurologic deficits were examined from 1 to 24 hours after occlusion of the middle cerebral artery and size of infarction was measured at 24 hours postocclusion. When KB-2796 (10 mg/kg, IP) was given immediately after, or 1 hour after, middle cerebral artery occlusion, marked improvement in neurologic score was seen 1 to 3 hours postocclusion. When given immediately after middle cerebral artery occlusion, size of infarction was also markedly smaller when compared with the control rat. The present study suggests that the calcium 2+ antagonist KB-2796 has brain-protective effects against ischemia even with its administration after induction of ischemia.
在局灶性脑缺血大鼠模型中研究了新型钙通道拮抗剂KB-2796对神经功能转归和梗死灶大小的影响。在大脑中动脉闭塞后1至24小时检查神经功能缺损情况，并在闭塞后24小时测量梗死灶大小。当在大脑中动脉闭塞后立即或1小时后给予KB-2796（10mg/kg，腹腔注射）时，在闭塞后1至3小时可见神经功能评分显著改善。当在大脑中动脉闭塞后立即给予时，与对照大鼠相比，梗死灶大小也明显更小。本研究表明，即使在缺血诱导后给予钙通道拮抗剂KB-2796，其对缺血仍具有脑保护作用。
