Mfuh Adelphe M, Nguyen Vu T, Chhetri Bhuwan, Burch Jessica E, Doyle John D, Nesterov Vladimir N, Arman Hadi D, Larionov Oleg V
Department of Chemistry, University of Texas at San Antonio , San Antonio, Texas 78249, United States.
Department of Chemistry, University of North Texas , Denton, Texas 76201, United States.
J Am Chem Soc. 2016 Jul 13;138(27):8408-11. doi: 10.1021/jacs.6b05436. Epub 2016 Jul 1.
We report herein a simple, additive- and metal-free, photoinduced, dual C-H/C-X borylation of chloro-, bromo-, and iodoarenes. The reaction produces 1,2- and 1,3-diborylarenes on gram scales under batch and continuous flow conditions. The regioselectivity of the dual C-H/C-X borylation is determined by the solvent and the substituents in the parent haloarenes.
我们在此报告一种简单的、无添加剂和金属的、光诱导的氯代芳烃、溴代芳烃和碘代芳烃的双C-H/C-X硼化反应。该反应在间歇和连续流动条件下能以克级规模制备1,2-和1,3-二硼芳基化合物。双C-H/C-X硼化反应的区域选择性由溶剂和母体卤代芳烃中的取代基决定。