Alkrad J Alyoussef, Shukla A, Mrestani Y, Neubert R H H
Pharmazie. 2016 May;71(5):258-62.
In this study the effect of dimethylsulfoxide (DMSO) radii on the droplets and on the required non-ionic surfactant volume for preparing water-in-oil microemulsions (MEs) was investigated. Five series of MEs were prepared either with the aid of isopropylpalmitate or medium chain triglycerides (MCTG) as continuous phases. The MEs were stabilized via either Tween80 or Span20 or a mixture of both. A mixture of water:DMSO (W:DMSO) with different ratios formed the colloidal phase of the first four MEs series. Only DMSO was used as colloidal phase of the fifth series. Dynamic light scattering (DLS) was used for measuring the radii of the droplets of MEs. The results showed that the consumed volumes of the surfactants were related to the W:DMSO ratio and the surfactant type. Moreover, the consumed surfactant volumes increased with decreasing radii of the droplets of the MEs. The MEs stabilized with Span20 had lower radii of the droplets (4-15 nm) than MEs stabilized by Tween80 (25-65 nm). It was evident that DMSO changed the interfacial tension which is reflected by changing the the volume of the surfactant consumed and by altering the droplets sizes. Consequently, DMSO acted as co-surfactant in stabilizing the MEs by reducing the required volumes of the surfactant which is important for reducing their toxicity.
在本研究中，研究了二甲基亚砜（DMSO）半径对液滴以及对制备油包水微乳液（MEs）所需的非离子表面活性剂体积的影响。借助棕榈酸异丙酯或中链甘油三酯（MCTG）作为连续相制备了五组微乳液。这些微乳液通过吐温80或司盘20或两者的混合物进行稳定。不同比例的水与DMSO（W:DMSO）混合物构成了前四组微乳液系列的胶体相。第五组仅使用DMSO作为胶体相。使用动态光散射（DLS）测量微乳液液滴的半径。结果表明，表面活性剂的消耗量与W:DMSO比例和表面活性剂类型有关。此外，随着微乳液液滴半径的减小，表面活性剂的消耗量增加。用司盘20稳定的微乳液的液滴半径（4 - 15纳米）比用吐温80稳定的微乳液（25 - 65纳米）小。很明显，DMSO改变了界面张力，这通过改变表面活性剂的消耗量和改变液滴大小得以体现。因此，DMSO通过减少表面活性剂的所需体积，在稳定微乳液方面起到了助表面活性剂的作用，这对于降低其毒性很重要。
