Lan A P, Chen J, Chai Z F, Hu Y
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China.
School of Radiological and Interdisciplinary Sciences, Soochow University, Suzhou, 215123, China.
Biometals. 2016 Aug;29(4):665-78. doi: 10.1007/s10534-016-9942-4. Epub 2016 Jun 27.
Parkinson's disease (PD) is the second most common neurodegenerative disease with gradual loss of dopaminergic neurons. Despite extensive research in the past decades, the etiology of PD remains elusive. Nevertheless, multiple lines of evidence suggest that oxidative stress is one of the common causes in the pathogenesis of PD. It has also been suggested that heavy metal-associated oxidative stress may be implicated in the etiology and pathogenesis of PD. Here we review the roles of redox metals, including iron, copper and cobalt, in PD. Iron is a highly reactive element and deregulation of iron homeostasis is accompanied by concomitant oxidation processes in PD. Copper is a key metal in cell division process, and it has been shown to have an important role in neurodegenerative diseases such as PD. Cobalt induces the generation of reactive oxygen species (ROS) and DNA damage in brain tissues.
帕金森病（PD）是第二常见的神经退行性疾病，多巴胺能神经元会逐渐丧失。尽管在过去几十年里进行了广泛研究，但PD的病因仍不明确。然而，多条证据表明氧化应激是PD发病机制的常见原因之一。也有人提出，与重金属相关的氧化应激可能与PD的病因和发病机制有关。在此，我们综述了氧化还原金属，包括铁、铜和钴，在PD中的作用。铁是一种高反应性元素，铁稳态失调在PD中伴随着氧化过程。铜是细胞分裂过程中的关键金属，已证明它在诸如PD等神经退行性疾病中起重要作用。钴会诱导脑组织中活性氧（ROS）的产生和DNA损伤。
