Pinheiro Alessandra C, Mendonça Nogueira Thais C, de Souza Marcus V N
FioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far-Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro - RJ, Brazil.
Anticancer Agents Med Chem. 2016;16(10):1339-52. doi: 10.2174/1871520616666160622090839.
Heterocyclic compounds are a class of substances, which play a critical role in modern drug discovery being incorporated in the structure of a large variety of drugs used in many different types of diseases. Quinoxaline is an important heterocyclic nucleus with a wide spectrum of biological activities, and recently much attention has been found on anticancer drug discovery based on this class. Owing to the importance of this system, the aim of this review is to provide an update on the synthesis and anticancer activity of quinoxaline derivatives covering articles published between 2010 and 2015.
杂环化合物是一类物质，在现代药物发现中起着关键作用，被纳入用于许多不同类型疾病的多种药物结构中。喹喔啉是一种具有广泛生物活性的重要杂环核，最近基于此类的抗癌药物发现受到了广泛关注。由于该体系的重要性，本综述的目的是提供2010年至2015年间发表的关于喹喔啉衍生物的合成及抗癌活性的文章的最新情况。
