Frazier Elisabeth A, Swenson Lance P, Mullare Tracy, Dickstein Daniel P, Hunt Jeffrey I
Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
Emma Pendleton Bradley Hospital, East Providence, RI, USA.
Child Psychiatry Hum Dev. 2017 Jun;48(3):393-399. doi: 10.1007/s10578-016-0666-z.
Depression with mixed features is poorly understood, especially in pediatric samples. This study compares symptoms and correlates of depressed adolescent inpatients with mixed features to inpatients with bipolar disorder and major depression. 407 adolescents were administered diagnostic interviews and self-reports, and 262 were categorized as Depression with Mixed Features (MXD; n = 38), Consensus Bipolar (CB; n = 79), or Depression Only (DO; n = 145). Demographic and morbidity information were collected via chart reviews. MXD adolescents evidenced elevated mania-related symptoms compared to DO adolescents. MXD adolescents had elevated Unusually Energetic symptoms and increases for six additional category B mania-related symptoms compared to CB adolescents. MXD adolescents met criteria for more comorbid disorders and reported elevated suicidality, anger, and trauma symptoms compared to CB and DO adolescents. Overall, MXD adolescents evidenced elevated symptomatology compared to other groups, suggesting mixed depression may represent a unique constellation of symptoms meriting further investigation.
伴有混合特征的抑郁症目前还鲜为人知，尤其是在儿科样本中。本研究比较了具有混合特征的抑郁青少年住院患者与双相情感障碍和重度抑郁症住院患者的症状及相关因素。对407名青少年进行了诊断访谈和自我报告，其中262人被分类为伴有混合特征的抑郁症（MXD；n = 38）、一致性双相情感障碍（CB；n = 79）或仅患有抑郁症（DO；n = 145）。通过病历审查收集人口统计学和发病率信息。与DO青少年相比，MXD青少年表现出与躁狂相关的症状有所增加。与CB青少年相比，MXD青少年的异常精力充沛症状有所增加，另外还有六种B类与躁狂相关的症状也有所增加。与CB和DO青少年相比，MXD青少年符合更多共病障碍的标准，且报告有更高的自杀倾向、愤怒和创伤症状。总体而言，与其他组相比，MXD青少年表现出更高的症状水平，这表明混合性抑郁症可能代表了一组独特的症状群，值得进一步研究。
