阿曼女性孕期及产后幽门螺杆菌IgA抗体水平较高。
High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery.
作者信息
Al-Balushi Mohammed Said, Said Elias Anthony, Hasson Sidgi Syed, Al-Busaidi Juma Zaid, Al-Reesi Iman, Idris Mohammed, Al-Ghafri Wadha, Al-Kalbani Moza, Al-Jabri Ali Abdullah
机构信息
Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman, E mail:
出版信息
Iran J Immunol. 2016 Jun;13(2):114-23.
BACKGROUND
Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood.
OBJECTIVES
To investigate the changes of the anti-H. pylori IgM, IgA and IgG levels in healthy Omani pregnant women during pregnancy and 3 months after delivery.
METHODS
Serum samples obtained from 70 Omani healthy pregnant women, with no history of autoimmune diseases, were tested for anti-H. pylori IgM, IgA and IgG in the first trimester of pregnancy and 3 months after delivery. In parallel and as a control group, sera obtained from a group of 70 healthy non-pregnant Omani women were tested. The levels of anti-H. pylori IgM, IgA and IgG were measured using standard Enzyme Linked Immunosorbent Assays (ELISAs).
RESULTS
Anti-H. pylori IgA levels were found to be significantly higher during pregnancy (p=0.046) and after delivery (p=0.02) when compared to the control group. Moreover, a significant increase in the levels of anti-H. pylori IgM, IgA and IgG was detected after delivery (p=0.002) when compared to the levels during pregnancy.
CONCLUSION
Pregnancy is associated with an increase in the levels of anti-H. pylori IgA antibodies. In addition, anti-H. pylori IgM, IgG and IgA antibody levels increase after delivery.
背景
幽门螺杆菌（H. pylori）是孕妇中常见的感染菌，伴有IgM、IgA和IgG抗体亚型水平的变化。孕期及产后抗幽门螺杆菌抗体的变化情况，以及它们为母亲和胎儿提供的保护程度尚未完全明确。
目的
研究阿曼健康孕妇孕期及产后3个月抗幽门螺杆菌IgM、IgA和IgG水平的变化。
方法
收集70名无自身免疫性疾病史的阿曼健康孕妇的血清样本，在孕早期及产后3个月检测抗幽门螺杆菌IgM、IgA和IgG。同时，收集70名健康非孕阿曼女性的血清作为对照组进行检测。采用标准酶联免疫吸附测定（ELISA）法测定抗幽门螺杆菌IgM、IgA和IgG水平。
结果
与对照组相比，孕期（p = 0.046）及产后（p = 0.02）抗幽门螺杆菌IgA水平显著升高。此外，与孕期水平相比，产后抗幽门螺杆菌IgM、IgA和IgG水平显著升高（p = 0.002）。
结论
孕期与抗幽门螺杆菌IgA抗体水平升高有关。此外，产后抗幽门螺杆菌IgM、IgG和IgA抗体水平升高。
Zotero 插件