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[酒精动机与大鼠大脑情感区域功能状态的关系]

[Relation of alcoholic motivation to the functional state of the emotive zones of the brain in rats].

作者信息

Bondarenko T T

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1989 Jan-Feb;39(1):72-5.

PMID:2735134
Abstract

Reactions of neurones pair of positive and negative emotiogenic hypothalamus zones to electrocutaneous stimulation and to intraperitoneal administration of ethanol solution (2 g/kg) were studied in outbred male rats with previously determined attitude to alcohol. In animals who preferred alcohol the neurones of the negative zone were significantly more reactive, and in animals who preferred water the neurones of the positive zone were more reactive. In both studied groups of rats, in most cases ethanol had an inhibitory influence on impulse activity of negative zone neurones, but it acted differently on positive zone neurones: in most cases it intensified neurones impulse activity in rats preferring alcohol and significantly inhibited it in animals rejecting alcohol.

摘要

在先前已确定对酒精态度的远交系雄性大鼠中,研究了正负情绪发生下丘脑区域的神经元对皮肤电刺激和腹腔注射乙醇溶液(2克/千克)的反应。在偏好酒精的动物中,负区的神经元反应性明显更高,而在偏好水的动物中,正区的神经元反应性更高。在两组受试大鼠中,大多数情况下乙醇对负区神经元的冲动活动有抑制作用,但对正区神经元的作用不同:在大多数情况下,它增强了偏好酒精的大鼠的神经元冲动活动,而在拒绝酒精的动物中则显著抑制了这种活动。

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