中国精神分裂症患者群体的指长比（2D:4D）
Digit ratio (2D:4D) in a Chinese population with schizophrenia.
作者信息
Qian Wenli, Huo Zhenghao, Lu Hong, Sheng Youjing, Geng Zhi, Ma Zhanbing
机构信息
Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education/ Key Laboratory of Reproduction and Genetics/ Department of Medical Genetic and Cell Biology, Yinchuan 750004, PR China.
Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education/ Key Laboratory of Reproduction and Genetics/ Department of Medical Genetic and Cell Biology, Yinchuan 750004, PR China.
出版信息
Early Hum Dev. 2016 Jul;98:45-8. doi: 10.1016/j.earlhumdev.2016.05.003. Epub 2016 Jun 25.
BACKGROUND
Prenatal gonadal hormones may play a major role in pathogenesis of schizophrenia. It has been reported that second to fourth digit ratio (2D:4D) was influenced by the levels of exposure to prenatal testosterone and estrogen. So, 2D:4D may help to predict the disease susceptibility to schizophrenia.
AIMS
The aim of this study was to investigate the relationship between the digit ratio (2D:4D) and schizophrenia in Chinese population.
METHODS
We recruited 178 schizophrenics (males: 76; females: 102) and 365 controls (males: 218; females: 147) in this study. Photocopies of both hands were collected and left hand, right hand, mean hand and left minus right hand (DL-R) 2D:4D were analyzed.
RESULTS
The right and mean hand 2D:4D ratios were significantly higher in schizophrenics compared to that of controls in both males and females. The left hand 2D:4D ratio in female schizophrenics was also significantly higher than in controls. Compared to controls, the DL-R 2D:4D in male schizophrenics was obviously higher. There was a weakly (but not significantly) negative correlation between the mean hand 2D:4D ratio and the age of onset.
CONCLUSIONS
The 2D:4D ratio may correlate with the schizophrenia in Chinese population, and it may be an indicator of schizophrenia.
背景
产前性腺激素可能在精神分裂症的发病机制中起主要作用。据报道，食指与无名指比例（2D:4D）受产前睾酮和雌激素暴露水平的影响。因此，2D:4D可能有助于预测精神分裂症的疾病易感性。
目的
本研究旨在调查中国人群中手指比例（2D:4D）与精神分裂症之间的关系。
方法
本研究招募了178名精神分裂症患者（男性：76名；女性：102名）和365名对照者（男性：218名；女性：147名）。收集双手的影印件，并分析左手、右手、平均手以及左手减去右手（DL-R）的2D:4D。
结果
在男性和女性中，精神分裂症患者的右手和平均手2D:4D比例均显著高于对照者。女性精神分裂症患者的左手2D:4D比例也显著高于对照者。与对照者相比，男性精神分裂症患者的DL-R 2D:4D明显更高。平均手2D:4D比例与发病年龄之间存在弱（但不显著）负相关。
结论
2D:4D比例可能与中国人群中的精神分裂症相关，并且可能是精神分裂症的一个指标。
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