食指与无名指长度比值（2D:4D）与冠心病
Second to fourth digit ratio (2D:4D) and coronary heart disease.
作者信息
Lu Hong, Ma Zhanbing, Zhao Junli, Huo Zhenghao
机构信息
Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetics, Department of Medical Genetic and Cell Biology, Yinchuan 750004, PR China.
Medical Reproductive Center, General Hospital, Ningxia Medical University, Yinchuan 750004, PR China.
出版信息
Early Hum Dev. 2015 Jul;91(7):417-20. doi: 10.1016/j.earlhumdev.2015.04.009. Epub 2015 May 15.
INTRODUCTION
Sex steroid exposure during human development may influence disease susceptibility. Second to fourth digit ratio (2D:4D) is thought to be a putative biomarker for prenatal hormone level during foetal life. Recently there has been a great deal of interest in 2D:4D and risk of disease in adulthood.
METHODS
We explored the relationship between 2D:4D ratio and coronary heart disease. Photocopies of the two hands of 310 males (controls: 155; patients: 155) were collected at Yin chuan city, in the Ningxia province of China. Left hand, right hand, mean hand and right minus left 2D:4D (Dr-l) were analysed.
RESULTS
The mean values of 2D:4D ratio in patients were higher than those of CSIN controls. The patients showed significantly higher 2D:4D (left hand: P < 0.01; right hand, mean hand: P < 0.05) than controls. In patients, 2D:4D (especially left hand 2D:4D) were inversely associated with age at diagnosis (left hand: P < 0.001; right hand, mean hand: P < 0.05). No association between Dr-l and age or age at presentation of disease was observed in the groups.
CONCLUSION
2D:4D may correlate particularly with risk of coronary heart disease in Chinese men.
引言
人类发育过程中接触性类固醇可能会影响疾病易感性。食指与无名指比例（2D:4D）被认为是胎儿期产前激素水平的一种假定生物标志物。最近，人们对2D:4D与成年期疾病风险产生了浓厚兴趣。
方法
我们探讨了2D:4D比例与冠心病之间的关系。在中国宁夏银川市收集了310名男性（对照组：155人；患者组：155人）两只手的影印件。对左手、右手、双手均值以及右手减去左手的2D:4D（Dr-l）进行了分析。
结果
患者组的2D:4D比例均值高于对照组。患者组的2D:4D（左手：P < 0.01；右手、双手均值：P < 0.05）显著高于对照组。在患者中，2D:4D（尤其是左手2D:4D）与诊断时的年龄呈负相关（左手：P < 0.001；右手、双手均值：P < 0.05）。在各研究组中，未观察到Dr-l与年龄或疾病出现时的年龄之间存在关联。
结论
2D:4D可能尤其与中国男性的冠心病风险相关。
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