Li Ya-Li, Xie Hui, Musha Halida, Xing Ying, Mei Cai-Xia, Wang Hai-Jiao, Wulasihan Muhuyati
VIP Department, First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830011, China.
Basic Medical College, Xinjiang Medical University, Urumqi, 830011, China.
Cell Biochem Biophys. 2015 Jul;72(3):643-7. doi: 10.1007/s12013-014-0346-1.
Recent years, we has witnessed a sharp increase in the complications of Type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Here we aimed to determine the risk factors for T2DM patients with NAFLD and the relationship of serum uric acid (SUA) in these complications. We performed retrospective analysis of 300 T2DM patients admitted into our hospital from April 2010 to January 2014. We divided the T2DM patients into two groups based on whether the patients also had NAFLD or not, Group A (without NAFLD, 155 cases) and Group B (with NAFLD, 145 cases). General information of the patients was collected and analyzed statistically. Meanwhile, we detected and compared the blood biochemistry, glucose, and fasting insulin (FINS), and further performed Logistic regression analysis and determined the risk factors in T2DM patients with NAFLD. Significantly higher BMI, waist circumference, hip circumference, WHR, systolic, and diastolic blood pressure were observed in T2DM patients with NAFLD than the patients without NAFLD, which were statistically different (P < 0.05). There were also significant higher levels of TC, TG, ALT, AST, GGT, and SUA in T2DM patients with NAFLD than those in patients without NAFLD, which were statistically different (P < 0.05). Significantly higher levels of FPG, FINS, and HOMA-IR were observed in the T2DM patients with NAFLD than those without, which were statistically significant (P < 0.05). Logistic regression analysis also showed high BMI, WHR, TG, and SUA were independent risk factors in T2DM patients with NAFLD (P < 0.05). Meanwhile, SUA levels were positively correlated with BMI, W, H, WHR, hip circumference, waist circumference, TG, ALT, AST, GGT, FPG, FINS, and HOMA-IR, which were statistically significant (P < 0.05). The risk factors for T2DM patients with NAFLD are mainly BMI, WHR, TG, and SUA. Our findings provide clinical implications for the prevention and early diagnosis of T2DM patients with NAFLD.
近年来，我们目睹了2型糖尿病（T2DM）合并非酒精性脂肪性肝病（NAFLD）的并发症急剧增加。在此，我们旨在确定T2DM合并NAFLD患者的危险因素以及血清尿酸（SUA）在这些并发症中的关系。我们对2010年4月至2014年1月期间我院收治的300例T2DM患者进行了回顾性分析。根据患者是否合并NAFLD，将T2DM患者分为两组，A组（无NAFLD，155例）和B组（有NAFLD，145例）。收集患者的一般资料并进行统计学分析。同时，我们检测并比较了血液生化、血糖和空腹胰岛素（FINS），并进一步进行Logistic回归分析，确定T2DM合并NAFLD患者的危险因素。与无NAFLD的患者相比，T2DM合并NAFLD的患者的BMI、腰围、臀围、腰臀比、收缩压和舒张压显著更高，差异有统计学意义（P<0.05）。T2DM合并NAFLD的患者的总胆固醇（TC）、甘油三酯（TG）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转肽酶（GGT）和SUA水平也显著高于无NAFLD的患者，差异有统计学意义（P<0.05）。与无NAFLD的T2DM患者相比，合并NAFLD的T2DM患者的空腹血糖（FPG）、FINS和稳态模型胰岛素抵抗指数（HOMA-IR）水平显著更高，差异有统计学意义（P<0.05）。Logistic回归分析还显示，高BMI、腰臀比、TG和SUA是T2DM合并NAFLD患者的独立危险因素（P<0.05）。同时，SUA水平与BMI、体重、身高、腰臀比、臀围、腰围、TG、ALT、AST、GGT、FPG、FINS和HOMA-IR呈正相关，差异有统计学意义（P<0.05）。T2DM合并NAFLD患者的危险因素主要是BMI、腰臀比、TG和SUA。我们的研究结果为T2DM合并NAFLD患者预防和早期诊断提供了临床依据。
