Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, USA.
Department of Anesthesiology, Stony Brook School of Medicine, Stony Brook, NY, USA.
Anaesth Crit Care Pain Med. 2016 Dec;35(6):417-421. doi: 10.1016/j.accpm.2016.03.005. Epub 2016 Jun 21.
Transient neurologic symptoms (TNS) led to the abandonment of intrathecal lidocaine. We reviewed the published literature for information about the duration of action and side effects of intrathecal prilocaine, which has been recently reintroduced in Europe. Medline and EMBASE databases were searched for the time period from 1966 to 2015. Fourteen prospective and one retrospective study were retrieved. The duration of the surgical block can be adjusted using doses between 40 and 80mg. Hyperbaric prilocaine in doses as low as 10mg can be used for perianal procedures. Four cases of TNS in 486 patients were reported in prospective studies, and none in 5000 cases in a retrospective data set. Spinal prilocaine appears to be safe and reliable for day case anesthesia. However, as chloroprocaine has a shorter duration and a lower risk of TNS and urinary retention, the indications for prilocaine remain to be defined.
短暂性神经症状（TNS）导致鞘内利多卡因的应用被放弃。我们查阅了已发表的文献，以了解最近在欧洲重新引入的鞘内普鲁卡因的作用持续时间和副作用。在 1966 年至 2015 年期间，我们在 Medline 和 EMBASE 数据库中进行了搜索。检索到 14 项前瞻性研究和 1 项回顾性研究。可以使用 40 至 80mg 的剂量来调整手术阻滞的持续时间。40mg 以下的超短效普鲁卡因可用于肛门周围手术。在前瞻性研究中，486 例患者中有 4 例出现 TNS，而在回顾性数据集的 5000 例中无 TNS 发生。椎管内普鲁卡因用于日间手术麻醉似乎安全可靠。然而，由于氯普鲁卡因的作用持续时间更短，TNS 和尿潴留的风险更低，因此普鲁卡因的适应证仍有待确定。
Zotero 插件