Pusceddu Sara, Femia Daniela, Lo Russo Giuseppe, Ortolani Silvia, Milione Massimo, Maccauro Marco, Vernieri Claudio, Prinzi Natalie, Concas Laura, Leuzzi Livia, De Braud Filippo, Buzzoni Roberto
a Department of Medical Oncology , Fondazione IRCCS 'Istituto Nazionale dei Tumori' , Milan , Italy.
b Department of Medical Oncology , Azienda Ospedaliera Universitaria Integrata, University of Verona , Verona , Italy.
Expert Rev Anticancer Ther. 2016 Sep;16(9):969-76. doi: 10.1080/14737140.2016.1207534. Epub 2016 Jul 13.
Small intestinal (SI) neuroendocrine tumors (NETs) are relatively rare tumors. Due to the lack of symptom or specific symptoms, SI-NETs are often diagnosed at an advanced stage, making therapy challenging. The management of patients with advanced stage SI-NETS requires a multidisciplinary approach that combines surgical and medical treatment including novel targeted molecular therapies.
This article summarizes current strategies for the medical treatment of SI-NETS. Expert commentary: The treatment plan of advanced-stage SI-NETs should be tailored in a case-by-case manner with the adoption of a multidisciplinary approach that combines different treatment options, including biological targeted therapies. In particular, we believe that the identification of the optimal treatment sequence(s), correct treatment timing and the selection of patients eligible to different treatments need specific investigation in controlled clinical trials.
小肠神经内分泌肿瘤（SI-NETs）是相对罕见的肿瘤。由于缺乏症状或症状不特异，SI-NETs常在晚期才被诊断出来，这使得治疗具有挑战性。晚期SI-NETs患者的管理需要多学科方法，将手术和药物治疗（包括新型靶向分子疗法）相结合。
本文总结了SI-NETs的当前药物治疗策略。
晚期SI-NETs的治疗方案应根据具体情况量身定制，采用多学科方法，结合不同的治疗选择，包括生物靶向治疗。特别是，我们认为确定最佳治疗顺序、正确的治疗时机以及选择适合不同治疗的患者需要在对照临床试验中进行具体研究。
