Cnops J, Kauffmann F, De Trez C, Baltz T, Keirsse J, Radwanska M, Muraille E, Magez S
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.
Parasite Immunol. 2016 Oct;38(10):642-7. doi: 10.1111/pim.12344. Epub 2016 Jul 28.
African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T. b. gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN-γ and TNF-α during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.
非洲锥虫病是一种在撒哈拉以南非洲大部分地区出现的使人衰弱的寄生虫病。布氏冈比亚锥虫占报告的人类非洲锥虫病感染病例的98%，并引发一种慢性、逐渐发展的疾病。多种锥虫病实验小鼠模型已证明，脾脏滤泡B（FoB）细胞会发生炎症依赖性凋亡，并且针对先前遇到的病原体的B细胞记忆遭到破坏。在此，我们报告，在小鼠感染慢性布氏冈比亚锥虫野外分离株期间，FoB细胞得以保留。这与感染急性期干扰素-γ和肿瘤坏死因子-α水平降低相一致。这一结果表明，在低毒力寄生虫的慢性感染中，引发的炎症较少，因此不会发生FoB细胞破坏。
