Su Chen-Hsien, Lane Hsien-Yuan, Hsiao Chieh-Lun, Liu Liang-Chih, Ji Hong-Xue, Li Hsin-Ting, Yen Shiou-Ting, Su Chung-Hao, Hsia Te-Chun, Chang Wen-Shin, Tsai Chia-Wen, Bau DA-Tian
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Anticancer Res. 2016 Jul;36(7):3341-5.
Metalloproteinases (MMPs) are a family of enzymes involved in many physiological processes, such as skeletal development, wound healing, and scar formation, as well as carcinogenesis. However, the contribution of MMP1 genotype to breast cancer has not been elucidated. This study aimed to evaluate the contribution of commonly studied MMP1 promoter 1607 genotype to breast cancer risk.
In this hospital-based case-control study, contribution of MMP1 genotype to breast cancer risk was evaluated among 1,232 patients with breast cancer and 1,232 gender-matched healthy controls.
The distribution of 2G/2G, 1G/2G and 1G/1G for MMP1 promoter 1607 genotype was 36.0%, 41.3% and 22.7% in the breast cancer group and 34.2%, 44.5% and 21.3% in the non-cancer group, respectively (p for trend=0.2820). We also analyzed the allelic frequency distributions and found that the variant 1G allele of MMP1 promoter 1607 conferred similar breast cancer susceptibility as the wild-type 2G allele (odds ratio=0.99, 95% confidence interval=0.89-1.11, p=0.8858). There was no interaction between MMP1 promoter 1607 genotype and cigarette smoking or alcohol drinking habits.
The genotype of MMP1 promoter 1607 may not be a major determining factor for breast cancer risk. The contribution of MMP1 promoter 1607 genotype to prognosis and subtypes of breast cancer needs further investigation.
金属蛋白酶（MMPs）是一类参与许多生理过程的酶，如骨骼发育、伤口愈合、瘢痕形成以及致癌作用。然而，MMP1基因型对乳腺癌的影响尚未阐明。本研究旨在评估常见的MMP1启动子1607基因型对乳腺癌风险的影响。
在这项基于医院的病例对照研究中，对1232例乳腺癌患者和1232例性别匹配的健康对照者评估MMP1基因型对乳腺癌风险的影响。
MMP1启动子1607基因型的2G/2G、1G/2G和1G/1G在乳腺癌组中的分布分别为36.0%、41.3%和22.7%，在非癌症组中分别为34.2%、44.5%和21.3%（趋势p值=0.2820）。我们还分析了等位基因频率分布，发现MMP1启动子1607的变异1G等位基因赋予的乳腺癌易感性与野生型2G等位基因相似（优势比=0.99，95%置信区间=0.89-1.11，p=0.8858）。MMP1启动子1607基因型与吸烟或饮酒习惯之间没有相互作用。
MMP1启动子1607的基因型可能不是乳腺癌风险的主要决定因素。MMP1启动子1607基因型对乳腺癌预后和亚型的影响需要进一步研究。
