Spiegel David R, Mccroskey Aidan L, Deyerle Branden A
All with the Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, Virginia.
Innov Clin Neurosci. 2016 Apr 1;13(3-4):32-41. eCollection 2016 Mar-Apr.
Transient global amnesia is a clinical syndrome characterized by the sudden onset of anterograde amnesia, accompanied by repetitive questioning, sometimes with a retrograde component, lasting up to 24 hours, without compromise of other neurologic function. Neuroimaging after an acutetransient global amnesia event often shows transient perturbation of specific hippocampal circuits that are involved in memory processing. Critical clinical distinctions, such as between transient global amnesia and other forms of transient amnesic episodes, as well as important clues to the underlying pathophysiologies are herein reviewed. Finally, we discuss the role of hippocampal insufficiency in the neurobiology of delusions.
短暂性全面性遗忘症是一种临床综合征,其特征为顺行性遗忘症突然发作,伴有反复提问,有时还伴有逆行性遗忘成分,持续长达24小时,且不伴有其他神经功能损害。急性短暂性全面性遗忘症发作后的神经影像学检查常显示参与记忆处理的特定海马回路出现短暂紊乱。本文回顾了短暂性全面性遗忘症与其他形式的短暂性遗忘发作之间的关键临床鉴别,以及潜在病理生理学的重要线索。最后,我们讨论了海马功能不全在妄想神经生物学中的作用。