Jamolowicz Anna I, Chen Huei-Yang, Panegyres Peter K
Neurodegenerative Disorders Research Pty Ltd, West Perth, WA, Australia.
Australas Med J. 2015 Mar 31;8(3):73-9. doi: 10.4066/AMJ.2015.2014. eCollection 2015.
Statins are a first-line drug treatment for hypercholesterolaemia. Recently there has been general public and media interest surrounding uses and side effects of statins, including memory loss.
We analysed an Australian experience in statin usage in an attempt to improve understanding of the relationship between statins and memory-related adverse events.
Total adverse events (TAE) and adverse events with single suspected medicines (SSM) for memory loss and other memory-related adverse events were searched for statin compounds from January 1992 to May 2013, using the Medicare Australia and Pharmaceutical Benefits Scheme (PBS) websites and Therapeutic Goods Administration (TGA) adverse events data. TAE and SSM were compared to the number of prescriptions by item number searched using the PBS. The process was repeated for non-statin cholesterol-lowering drugs.
The most common adverse event was amnesia (167 events for statins and six for non-statins). There were 239 TAE (incidence rate=0.88) listed for statins and 10 for non-statins (incidence rate=0.53). There were 217 SSM events listed for the statins (incidence rate = 0.08) and eight for the alternatives (incident rate=0.04). The differences between TAE and SSM incidence rates between statins and non-statins drugs were not significant (both p values >0.05).
We found that there were no differences in memory-related adverse events between statins and other cholesterol-lowering medications using Australian PBS and TGA adverse events data.
他汀类药物是高胆固醇血症的一线药物治疗。最近，公众和媒体对他汀类药物的用途和副作用，包括记忆力减退产生了普遍兴趣。
我们分析了澳大利亚他汀类药物的使用情况，以增进对他汀类药物与记忆相关不良事件之间关系的理解。
利用澳大利亚医疗保险和药品福利计划（PBS）网站以及治疗用品管理局（TGA）的不良事件数据，检索1992年1月至2013年5月期间他汀类化合物导致的总不良事件（TAE）以及与单一可疑药物相关的不良事件（SSM），这些不良事件涉及记忆力减退及其他与记忆相关的不良事件。将TAE和SSM与使用PBS按检索项目编号开具的处方数量进行比较。对非他汀类降胆固醇药物重复这一过程。
最常见的不良事件是失忆（他汀类药物导致167例事件，非他汀类药物导致6例）。他汀类药物列出239例TAE（发生率=0.88），非他汀类药物列出10例（发生率=0.53）。他汀类药物列出217例SSM事件（发生率 = 0.08），替代药物列出8例（发生率=0.04）。他汀类药物和非他汀类药物之间TAE和SSM发生率的差异不显著（p值均>0.05）。
利用澳大利亚PBS和TGA不良事件数据，我们发现他汀类药物与其他降胆固醇药物在记忆相关不良事件方面没有差异。
