睡眠时间、胰岛素敏感性与β细胞功能之间的关联：EGIR-RISC研究
The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Function: The EGIR-RISC Study.
作者信息
Rutters Femke, Besson Herve, Walker Mark, Mari Andrea, Konrad Thomas, Nilsson Peter M, Balkau Beverley, Dekker Jacqueline M
机构信息
Department of Epidemiology and Biostatistics (F.R., J.M.D.), Vrije Universiteit Medical Centre, 1081 BT Amsterdam, The Netherlands; EMGO+ Institute for Care Research (F.R., J.M.D.), Vrije Universiteit Medical Centre, Amsterdam, The Netherlands; PHARMO Institute for Drug Outcome Research (H.B.), Utrecht, The Netherlands; Institute of Cellular Medicine (M.W.), Medical School Newcastle University, Newcastle, United Kingdom; Institute of Neuroscience (A.M.), National Research Council, Padova, Italy; Institute for Metabolic Research (T.K.), Frankfurt, Germany; Department of Clinical Sciences (P.M.N.), Lund University and University Hospital Malmo, Lund, Sweden; and Inserm U1081CESP (B.B.), Centre for Research in Epidemiology and Population Health, Renal and Cardiovascular Epidemiology, Villejuif, France.
出版信息
J Clin Endocrinol Metab. 2016 Sep;101(9):3272-80. doi: 10.1210/jc.2016-1045. Epub 2016 Jun 29.
CONTEXT
In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing.
OBJECTIVE
To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort.
DESIGN, SETTING, PARTICIPANTS, AND MEASURES: We used data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and β-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and β-cell function were analyzed by multiple linear regression, stratified by sex.
RESULTS
In our current analysis, we included 788 participants (57% women, age 44 ± 8 y), who had an average sleep duration of 7.3 ± 1.5 hours. In men, we observed an inverted U-shaped association between sleep duration categorized per hour and M/I (in μmol/min per kgFFM/nM per hour) (β-estimate [95% confidence intervals] 41 [2, 80]; P = .04 and β(2)-estimate -3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kgFFM) (β-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and β-cell function (in pmol/min per m(2)/mM per hour) (β-estimate -45 [-86, -3]; P = .04 and β(2)-estimate 3 [0.2, 6]; P = .04).
CONCLUSIONS
Sleep duration is associated with insulin sensitivity and β-cell function in a sex-specific manner in clinically healthy people.
背景
在过去十年中，超过三十多项研究报告了自我报告的短睡眠与葡萄糖代谢紊乱之间的关系。然而，一项根据金标准高胰岛素正葡萄糖钳夹技术评估胰岛素敏感性的研究仍然缺失。
目的
在欧洲胰岛素抵抗研究组（EGIR-RISC）队列研究中，评估睡眠时间与胰岛素敏感性和β细胞功能之间的横断面关联。
设计、地点、参与者和测量方法：我们使用了来自欧洲多中心EGIR-RISC研究基线测量的数据，该研究包括1319名临床健康参与者。使用单轴加速度计测量睡眠和身体活动。通过高胰岛素正葡萄糖钳夹技术并根据口服葡萄糖胰岛素敏感性指数模型，利用口服葡萄糖耐量试验来估计胰岛素敏感性和β细胞功能。通过多元线性回归分析睡眠时间与胰岛素敏感性和β细胞功能之间的关联，并按性别分层。
结果
在我们当前的分析中，纳入了788名参与者（57%为女性，年龄44±8岁），他们的平均睡眠时间为7.3±1.5小时。在男性中，我们观察到按小时分类的睡眠时间与M/I（每千克去脂体重每分钟微摩尔数/每小时纳摩尔数）之间呈倒U形关联（β估计值[95%置信区间]为41[2,80]；P = 0.04，β(2)估计值为-3[-6,-0.2]，P = 0.04），以及口服葡萄糖胰岛素敏感性指数（每千克去脂体重每分钟毫升数）有上升趋势（β估计值[95%置信区间]为0.8[-0.4,2]；P = 0.17）。在女性中，我们观察到睡眠时间与β细胞功能（每平方米每分钟皮摩尔数/每小时毫摩尔数）之间呈U形关联（β估计值为-45[-86,-3]；P = 0.04，β(2)估计值为3[0.2,6]；P = 0.04）。
结论
在临床健康人群中，睡眠时间与胰岛素敏感性和β细胞功能存在性别特异性关联。
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