Stanimirovic Andrija, Kovacevic Maja, Korobko Igor, Šitum Mirna, Lotti Torello
Department of Clinical Medicine, University of Applied Health Sciences, Zagreb, Croatia.
Croatian Vitiligo Association, Zagreb, Croatia.
Dermatol Ther. 2016 Sep;29(5):312-316. doi: 10.1111/dth.12363. Epub 2016 Jun 30.
Vitiligo is depigmenting disorder of the skin and mucous membranes but despite various therapeutic options, complete and satisfactory treatment of vitiligo still remains a challenge. Therapeutic success also varies depending on the localization of lesions; hands and bony prominents are considered to be resistant to treatment. We investigated feasibility of treating resistant bilateral symmetrical vitiligo vulgaris and acrofacialis lesions with combination of narrowband UVB and topical prostaglandins (0.005% latanoprost solution) with or without Dermaroller 0.5 mm needle length-assisted microneedling. Frequency of repigmentation onset was generally low (37.8%) and pronounced repigmentation was infrequently seen (26-50% repigmentation in 20.8%, and >50% repigmentation in only 8.8% of repigmenting lesions). Our study, however, showed that latanoprost can be used in combination with NB-UVB phototherapy to induce repigmentation in some vitiligo lesions in resistant-to-treatment location, while addition of skin microneedling seems not to improve the treatment outcome and possibly needs modification.
白癜风是一种皮肤和黏膜色素脱失性疾病，尽管有多种治疗方法，但白癜风的完全且令人满意的治疗仍然是一项挑战。治疗效果也因皮损部位而异；手部和骨突出部位被认为对治疗有抵抗性。我们研究了窄谱中波紫外线（NB-UVB）与外用前列腺素（0.005%拉坦前列素溶液）联合使用，无论有无0.5毫米针长的 Dermaroller 辅助微针治疗双侧对称性寻常型白癜风和肢端颜面型白癜风抗治疗性皮损的可行性。色素再生开始的频率通常较低（37.8%），明显的色素再生很少见（20.8%的色素再生性皮损色素再生26%-50%，仅8.8%的色素再生性皮损色素再生>50%）。然而，我们的研究表明，拉坦前列素可与NB-UVB光疗联合使用，以诱导抗治疗部位某些白癜风皮损的色素再生，而添加皮肤微针似乎并不能改善治疗效果，可能需要改进。
