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多中心队列研究“职业性皮肤病康复——住院管理的优化与质量保证(ROQ)”:3年随访结果

Multicentre cohort study 'Rehabilitation of Occupational Skin Diseases - Optimization and Quality Assurance of Inpatient Management (ROQ)': results from a 3-year follow-up.

作者信息

Brans Richard, Skudlik Christoph, Weisshaar Elke, Scheidt Reginald, Ofenloch Robert, Elsner Peter, Wulfhorst Britta, Schönfeld Michael, John Swen M, Diepgen Thomas L

机构信息

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, 49090 Osnabrück, Germany.

Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabrück and Dermatologic Centre, Trauma Hospital, 21033 Hamburg, Germany.

出版信息

Contact Dermatitis. 2016 Oct;75(4):205-12. doi: 10.1111/cod.12614. Epub 2016 Jun 29.

Abstract

BACKGROUND

A tertiary individual prevention programme (TIP) is offered to patients with severe occupational skin disease (OSD) in Germany. Previously, it was shown that the burden of OSDs is considerably reduced in patients up to 1 year after the TIP.

OBJECTIVES

To evaluate the long-term effects of the TIP.

PATIENTS AND METHODS

In a prospective multicentre cohort study, the clinical and patient-reported outcome data 3 years after the TIP were evaluated.

RESULTS

Of the 1788 patients initially included in the study, 1410 were available for the 3-year follow-up analysis. The severity of OSD, the use of topical corticosteroids and days of absence from work were significantly reduced 3 years after the TIP, and the quality of life and skin protective behaviour were significantly improved. Of the patients, 96.9% were able to resume work. One thousand one hundred and sixty-six patients (82.7%) were still working 3 years after the TIP, 874 of them (75.0%) in the same occupational field. Hairdressers had the lowest rate of remaining in their original profession (41.3%).

CONCLUSIONS

The follow-up during 3 years of this unique cohort of patients with OSDs shows that the TIP is associated with sustained improvements in terms of disease severity, ability to work, quality of life, and prognosis.

摘要

背景

德国为患有严重职业性皮肤病(OSD)的患者提供三级个体预防计划(TIP)。此前研究表明,在接受TIP后的1年内,患者的OSD负担显著减轻。

目的

评估TIP的长期效果。

患者与方法

在一项前瞻性多中心队列研究中,对接受TIP 3年后的临床和患者报告结局数据进行评估。

结果

最初纳入研究的1788例患者中,1410例可用于3年随访分析。TIP 3年后,OSD的严重程度、外用糖皮质激素的使用情况和缺勤天数显著降低,生活质量和皮肤保护行为显著改善。96.9%的患者能够恢复工作。1166例患者(82.7%)在接受TIP 3年后仍在工作,其中874例(75.0%)从事相同职业领域的工作。美发师留在原职业的比例最低(41.3%)。

结论

对这一独特的OSD患者队列进行的3年随访表明,TIP在疾病严重程度、工作能力、生活质量和预后方面带来持续改善。

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