Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.
Universität Osnabrück, Osnabrück, Germany.
Handb Exp Pharmacol. 2022;268:449-470. doi: 10.1007/164_2021_511.
Allergies are a major public health burden, and targeted measures are required in terms of prevention and treatment. The most common allergic conditions encompass atopic dermatitis (AD), food allergy (FA), allergic asthma (AA), and allergic rhino-conjunctivitis (AR). Primary prevention aims at preventing the onset of allergic disease, before the disease process begins. Secondary prevention aims at preventing progression and exacerbation of allergic disease whereas tertiary prevention aims at reducing disease burden in patients with established disease, by allergen immunotherapy (AIT) or medical rehabilitation. Rehabilitation programs are used for treatment of AA and AD and usually consist of extensive patient assessment, optimization of treatment management, patient education, and behavioral interventions, ideally involving a multidisciplinary treatment team and sometimes provided in a specific climate, usually alpine or maritime. Similarly, prevention of occupational skin diseases requires interdisciplinary approaches on the level of secondary and tertiary preventive intervention; if this is provided, then prevention programs have proven highly (cost-) effective. Unfortunately, the recently published Minimal Standards of Prevention of these dermatoses, underlining especially the importance of meticulous allergological diagnosis and subsequent multidisciplinary patient education, are so far being adhered to only in very few European countries.
过敏是一个主要的公共卫生负担,需要针对预防和治疗采取有针对性的措施。最常见的过敏情况包括特应性皮炎(AD)、食物过敏(FA)、过敏性哮喘(AA)和过敏性鼻结膜炎(AR)。一级预防旨在在疾病过程开始之前预防过敏疾病的发生。二级预防旨在预防过敏疾病的进展和恶化,而三级预防旨在通过过敏原免疫疗法(AIT)或医疗康复来减轻已确诊疾病患者的疾病负担。康复计划用于治疗 AA 和 AD,通常包括广泛的患者评估、治疗管理的优化、患者教育和行为干预,理想情况下涉及多学科治疗团队,有时在特定的气候条件下提供,通常是高山或海洋性气候。同样,职业性皮肤病的预防需要在二级和三级预防干预层面上采取跨学科的方法;如果提供了这些方法,那么预防计划已被证明具有很高的(成本)效益。不幸的是,最近发表的这些皮肤病的最低预防标准,特别强调了细致的过敏学诊断和随后的多学科患者教育的重要性,但迄今为止,只有极少数欧洲国家遵守这些标准。