Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007, Tarragona, Spain.
Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys 23, 08010, Barcelona, Spain.
Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11207-11. doi: 10.1002/anie.201605162. Epub 2016 Jun 30.
A user-friendly, nickel-catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.
本文描述了一种镍催化的、易于使用的还原酰胺化反应，可将未活化的伯、仲和叔烷基溴与异氰酸酯反应。这种催化策略在温和条件下，通过避免使用化学计量和敏感的有机金属试剂，提供了一种高效合成广泛的脂肪族酰胺的方法，具有优异的化学选择性。
