Ratto G B, Di Primio R, Romano P, Sacco A, Zaccheo D, Motta G
Ann Chir. 1989;43(4):311-4.
A new type of vascular prosthesis made of pyrolytic carbon fibres, was tested on growing pigs. Fourteen graft (8 x 30 mm) were implanted as inferior vena cava (IVC) substitutes. The blood conduits were removed 15 s, 60 min and 7, 15, 30, 60 and 120 days after implantation. Specimens were examined by light and scanning electron microscopy. Ten similar pigs underwent excision and re-implantation of 30 mm segment of IVC, and where used as controls. Carbon fibres grafts removed within 7 days after implantation were patent: at the subsequent observation times, the prosthetic segments appeared completely or partially thrombosed. Four of the 10 venous autografts failed. Shortly after implantation, a thick neointimal layer covered the inner surface of carbon grafts. This phenomenon delayed organization and neo-endothelialization of the neointima, exposing carbon segments to blood deposits.
一种由热解碳纤维制成的新型血管假体在生长猪身上进行了测试。植入了14个移植物（8×30毫米）作为下腔静脉（IVC）替代品。在植入后15秒、60分钟以及7、15、30、60和120天取出血管导管。通过光学显微镜和扫描电子显微镜检查标本。十只相似的猪接受了30毫米IVC段的切除和再植入，并用作对照。植入后7天内取出的碳纤维移植物通畅：在随后的观察时间，假体段出现完全或部分血栓形成。10个静脉自体移植物中有4个失败。植入后不久，一层厚厚的新生内膜覆盖了碳移植物的内表面。这种现象延迟了新生内膜的机化和新内皮化，使碳段暴露于血液沉积物中。
