Cui L, Sun M M, Zhao Z H, Yang J P, Zheng Y P, He L L, Chen K S, Fan Q X
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
Department of Pathology, Henan Cancer Hospital, Zhengzhou city, PR China.
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2):485-90.
The objective of the present study was to report the clinical significance of bladder cancer specific nuclear matrix protein 4 (BLCA-4) and urinary bladder cancer (UBC) on early diagnosis of bladder cancers. Enzyme-linked immunosorbent assay (ELISA) was used to detect BLCA-4 and UBC of 56 bladder cancer patients and 26 patients with urinary tract benign diseases, serving as controls. Urine exfoliated cell test was performed, and then the significance of BLCA-4 and UBC on the diagnosis of bladder cancers was analyzed. The sensitivity of BLCA-4 and UBC of the bladder cancer patients was significantly higher than that of the urine exfoliated cell test (P less than 0.05). The difference of BLCA-4 and UBC was not significant (P >0.05). The difference of BLCA-4 and UBC in the tumors with different gradings and stagings was not significant (P >0.05). Combined detection of BLCA-4 and UBC could improve the diagnosis sensitivity and specificity of bladder cancers with the advantages of high maneuverability, repeatability and objective results.
本研究的目的是报告膀胱癌特异性核基质蛋白4（BLCA-4）和膀胱癌抗原（UBC）对膀胱癌早期诊断的临床意义。采用酶联免疫吸附测定（ELISA）检测56例膀胱癌患者和26例尿路良性疾病患者（作为对照）的BLCA-4和UBC。进行尿液脱落细胞检测，然后分析BLCA-4和UBC对膀胱癌诊断的意义。膀胱癌患者BLCA-4和UBC的敏感性显著高于尿液脱落细胞检测（P<0.05）。BLCA-4和UBC之间的差异无统计学意义（P>0.05）。不同分级和分期肿瘤中BLCA-4和UBC的差异无统计学意义（P>0.05）。联合检测BLCA-4和UBC可提高膀胱癌诊断的敏感性和特异性，具有可操作性强、重复性好和结果客观的优点。
