Wong Ka-Kit, Gandhi Arpit, Viglianti Benjamin L, Fig Lorraine M, Rubello Domenico, Gross Milton D
Ka-Kit Wong, Arpit Gandhi, Milton D Gross, Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI 48109-5028, United States.
World J Radiol. 2016 Jun 28;8(6):635-55. doi: 10.4329/wjr.v8.i6.635.
To review the benefits of single photon emission computed tomography (SPECT)/computed tomography (CT) hybrid imaging for diagnosis of various endocrine disorders.
We performed MEDLINE and PubMed searches using the terms: "SPECT/CT"; "functional anatomic mapping"; "transmission emission tomography"; "parathyroid adenoma"; "thyroid cancer"; "neuroendocrine tumor"; "adrenal"; "pheochromocytoma"; "paraganglioma"; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts (case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this technology.
The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the bio-distribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for (99m)Tc-sestamibi parathyroid scintigraphy and (99m)Tc-pertechnetate thyroid scintigraphy, (123)I- or (131)I-radioiodine for staging of differentiated thyroid carcinoma, (111)In- and (99m)Tc- labeled somatostatin receptor analogues for detection of neuroendocrine tumors, (131)I-norcholesterol (NP-59) scans for assessment of adrenal cortical hyperfunction, and (123)I- or (131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and paraganglioma.
SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating to improved diagnostic accuracy and meaningful impact on patient care.
综述单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）融合成像在诊断各种内分泌疾病中的优势。
我们使用以下检索词在MEDLINE和PubMed数据库中进行检索：“SPECT/CT”；“功能解剖定位”；“发射传输断层扫描”；“甲状旁腺腺瘤”；“甲状腺癌”；“神经内分泌肿瘤”；“肾上腺”；“嗜铬细胞瘤”；“副神经节瘤”，以识别2003年至2015年期间发表的英文相关文章。对文章的参考文献列表进行审查以识别其他相关文章。分析检索到的有关SPECT/CT在内分泌成像中应用的手稿（病例报告、综述、荟萃分析和摘要），以对该技术的实用性进行描述性综合分析。
SPECT/CT融合相机技术的出现使得能够同时采集多模态成像，并实现三维体积数据集的无缝融合。将描绘内分泌系统细胞过程和内分泌源性肿瘤的放射性示踪剂生物分布的功能信息与CT获得的解剖结构相结合，提高了闪烁扫描对一系列内分泌腺功能障碍的诊断能力。文献描述了SPECT/CT在（99m）锝-司他米比甲状旁腺闪烁扫描和（99m）锝-高锝酸盐甲状腺闪烁扫描、（123）I或（131）I放射性碘用于分化型甲状腺癌分期、（111）铟和（99m）锝标记的生长抑素受体类似物用于检测神经内分泌肿瘤、（131）I-胆固醇（NP-59）扫描用于评估肾上腺皮质功能亢进以及（123）I或（131）I-间碘苄胍成像用于评估嗜铬细胞瘤和副神经节瘤方面的优势。
SPECT/CT利用了放射性药物成像的功能信息与CT解剖结构之间的协同作用，从而提高了诊断准确性，并对患者护理产生了有意义的影响。
